Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

Dissections or ruptures of aortic aneurysms remain a leading cause of death in the
developed world, with the majority of deaths being preventable if individuals at risk are …

Abstract Aim The “2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic
Disease” provides recommendations to guide clinicians in the diagnosis, genetic evaluation …

Background Aortic aneurysms (AA) are pathological dilations of the aorta, associated with
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …

Aortic dissection is a life-threatening condition caused by a tear in the intimal layer of the
aorta or bleeding within the aortic wall, resulting in the separation (dissection) of the layers …

Background: Thoracic aortic aneurysms progressively enlarge and predispose to acute
aortic dissections. Up to 25% of individuals with thoracic aortic disease harbor an underlying …

Thoracic aortic diseases that involve progressive enlargement, acute dissection, or rupture
are influenced by the hemodynamic loads and mechanical properties of the wall. We have …

Thoracic aortic aneurysm is a potentially life-threatening condition in that it places patients at
risk for aortic dissection or rupture. However, our modern understanding of the pathogenesis …

Of the clinical practice guideline of the Japanese Circulation Society concerning aortic
diseases, the Guidelines on Diagnosis and Treatment of Aortic Dissection (first edition) were …

The importance of maintaining contractile function in aortic smooth muscle cells (SMCs) is
evident by the fact that heterozygous mutations in the major structural proteins or kinases …