[HTML][HTML] The oralome and its dysbiosis: New insights into oral microbiome-host interactions

A Radaic, YL Kapila - Computational and structural biotechnology journal, 2021 - Elsevier
The oralome is the summary of the dynamic interactions orchestrated between the
ecological community of oral microorganisms (comprised of up to approximately 1000 …

The Role of Porphyromonas gingivalis Outer Membrane Vesicles in Periodontal Disease and Related Systemic Diseases

Z Zhang, D Liu, S Liu, S Zhang, Y Pan - Frontiers in cellular and …, 2021 - frontiersin.org
Periodontal disease is a chronic infectious disease associated with a variety of bacteria,
which can cause damage to the periodontal support structure and affect a variety of systemic …

Hyperglycemia modulates M1/M2 macrophage polarization via reactive oxygen species overproduction in ligature‐induced periodontitis

B Zhang, Y Yang, J Yi, Z Zhao… - Journal of periodontal …, 2021 - Wiley Online Library
Background and objective Periodontitis in diabetic patients is characterized by enhanced
inflammation and aggravated tissue damage in comparison with that in non‐diabetic …

The oral microbiota is modified by systemic diseases

DT Graves, JD Corrêa, TA Silva - Journal of dental research, 2019 - journals.sagepub.com
Periodontal diseases are initiated by bacteria that accumulate in a biofilm on the tooth
surface and affect the adjacent periodontal tissue. Systemic diseases such as diabetes …

An update on the evidence for pathogenic mechanisms that may link periodontitis and diabetes

D Polak, L Shapira - Journal of clinical periodontology, 2018 - Wiley Online Library
Aim To provide an update of the review by Taylor (Journal of Clinical Periodontology, 2013,
40, S113) regarding the scientific evidence of the biological association between …

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

R Cheng, Z Wu, M Li, M Shao, T Hu - International journal of oral …, 2020 - nature.com
Abstract Interleukin (IL)-1β, a pro-inflammatory cytokine, was elevated and participates in
periodontitis. Not only the link between IL-1β and periodontitis was proved by clinical …

[HTML][HTML] Diabetes enhances IL-17 expression and alters the oral microbiome to increase its pathogenicity

E Xiao, M Mattos, GHA Vieira, S Chen, JD Corrêa… - Cell host & …, 2017 - cell.com
Diabetes is a risk factor for periodontitis, an inflammatory bone disorder and the greatest
cause of tooth loss in adults. Diabetes has a significant impact on the gut microbiota; …

Chronic complications of diabetes mellitus: a mini review

M Lotfy, J Adeghate, H Kalasz, J Singh… - Current diabetes …, 2017 - ingentaconnect.com
Introduction: Diabetes mellitus (DM) is a major metabolic disorder currently affecting over
350 million people worldwide. Also, another one billion people in the world are pre-diabetic …

Impact of the host response and osteoblast lineage cells on periodontal disease

M Zhou, DT Graves - Frontiers in immunology, 2022 - frontiersin.org
Periodontitis involves the loss of connective tissue attachment and alveolar bone. Single cell
RNA-seq experiments have provided new insight into how resident cells and infiltrating …

The bidirectional relationship between periodontal disease and diabetes mellitus—A review

I Păunică, M Giurgiu, AS Dumitriu, S Păunică… - Diagnostics, 2023 - mdpi.com
Periodontitis is a chronic inflammatory disease caused by the presence of a bacterial biofilm
known as dental plaque. This biofilm affects the supporting apparatus of the teeth, especially …