This review covers the literature published between January and December in 2018 for
marine natural products (MNPs), with 717 citations (706 for the period January to December …

Bolstered by recent advances in bioinformatics, genetics, and enzyme engineering, the field
of chemoenzymatic synthesis has enjoyed a rapid increase in popularity and utility. This …

Covering: up to mid-2020 Terpenoids, also called isoprenoids, are the largest and most
structurally diverse family of natural products. Found in all domains of life, there are over 80 …

Covering: up to July 2019 Terpene synthases (TSs) are responsible for generating much of
the structural diversity found in the superfamily of terpenoid natural products. These elegant …

Covering: Up to January 2020 Meroterpenoids derived from the polyketide 1, 3, 6, 8-
tetrahydroxynaphthalene (THN) are complex natural products produced exclusively by …

Conspectus Natural products are biosynthesized from a limited pool of starting materials via
pathways that obey the same chemical logic as textbook organic reactions. Given the …

Nature's repertoire of bio-halogenase enzymes is intriguing with halogenases from various
natural product biosynthetic clusters that carry out site and region-specific halogenation of …

The biosynthetic route to the napyradiomycin family of bacterial meroterpenoids has been
fully described 32 years following their original isolation and 11 years after their gene cluster …

The α, α‐dihalocarbonyl moiety is a bifunctional system with a gem‐dihalocarbon and a
carbonyl carbon in 1, 2‐fashion. This is one of the privileged scaffolds in medicinal chemistry …

We report the first total synthesis of (+)-granatumine A, a limonoid alkaloid with PTP1B
inhibitory activity, in ten steps. Over the course of this study, two key methodological …