The native chemical ligation reaction (NCL) involves reacting a C-terminal peptide thioester
with an N-terminal cysteinyl peptide to produce a native peptide bond between the two …

The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …

The design of artificial catalysts able to compete with the catalytic proficiency of enzymes is
an intense subject of research. Non-covalent interactions are thought to be involved in …

Darwinian evolution involves the inheritance and selection of variations in reproducing
entities. Selection can be based on, among others, interactions with the environment …

Self‐replication is a fundamental concept. The idea of an entity that can repeatedly create
more of itself has captured the imagination of many thinkers from von Neumann to …

Addressing the emergence of life from a systems biology perspective, this new edition has
undergone extensive revision, reflecting changes in scientific understanding and evolution …

Self-replicating molecules are likely to have played an important role in the origin of life, and
a small number of fully synthetic self-replicators have already been described. Yet it remains …

An RNA enzyme that catalyzes the RNA-templated joining of RNA was converted to a format
whereby two enzymes catalyze each other's synthesis from a total of four oligonucleotide …

The construction of complex protein folds relies on the precise conversion of a linear
polypeptide chain into a compact 3-dimensional structure. The interplay of forces that link …

The two-volume Encyclopedia of Supramolecular Chemistry offers authoritative, centralized
information on a rapidly expanding interdisciplinary field. User-friendly and high-quality …