Mammalian WNK kinases (WNKs) are serine/threonine kinases that contain four members,
WNK1–4. They function to maintain ion homeostasis and regulate blood pressure in …

Cerebrovascular diseases and their sequalae, such as ischemic stroke, chronic cerebral
hypoperfusion, and vascular dementia are significant contributors to adult disability and …

Background Astrogliosis and white matter lesions (WML) are key characteristics of vascular
contributions to cognitive impairment and dementia (VCID). However, the molecular …

SPAK inhibitor ZT-1a was previously shown to be neuroprotective in murine ischemic stroke
models. In this study, we further examined the efficacy of four ZT-1a derivatives (ZT-1c,-1d …

Background Vagus nerve stimulation (VNS) has a protective effect on neurological recovery
in ischaemic stroke. However, its underlying mechanism remains to be clarified. Ubiquitin …

Abstract Background The choroid plexus (ChP) helps maintain the homeostasis of the brain
by forming the blood-CSF barrier via tight junctions (TJ) at the choroid plexus epithelial cells …

Ubiquitin C-terminal hydrolase L1 (UCHL1) is a neuronal protein important in maintaining
axonal integrity and motor function and may be important in the pathogenesis of many …

The purpose of this review is to highlight transformative advances that have been made in
the field of biomolecular condensates with special emphasis on condensate material …

Gamma aminobutyric acid (GABA) is a critical inhibitory neurotransmitter in the central
nervous system that plays a vital role in modulating neuronal excitability. Dysregulation of …

Inflammation is the primary pathological process of myocardial ischemia/reperfusion injury
(MI/RI). 7-Hydroxyflavone (HF), a natural flavonoid with a variety of bioactivities, plays a …