Tumour hypoxia is progressively emerging as a common feature of prostate tumours
associated with poor prognosis. While the molecular basis of disease progression is …

Intratumoural hypoxia (low oxygen tension) is associated with aggressive disease and poor
prognosis. Hypoxia‐inducible factor‐1 is a transcription factor activated by hypoxia that …

Hypoxia-inducible factor 1α (HIF-1α) is upregulated by hypoxia and oncogenic signalling in
many solid tumours. Its regulation and function in thyroid carcinomas are unknown. We …

To improve the efficacy and selectivity of virotherapy for malignant glioma, we designed a
strategy to amplify adenoviral replication in conjunction with radiotherapy using a …

Tumor hypoxia is a main obstacle for radiation therapy. To investigate whether exposure to a
proton beam can overcome radioresistance in hypoxic tumor cells, three kinds of cancer …

Radiotherapy is a widely used treatment for localized malignancies that is often delivered in
combination with cytotoxic chemotherapeutic agents. The concept that treatment of localized …

Thyroid cancer (TC) is an endocrine related cancer and is well coupled with the female
reproductive hormone, 17β‐estradiol (estrogen). Plenty of articles have discussed the role of …

Proton beam therapy can kill tumor cells while saving normal cells because of its specific
energy delivery properties and so is used to various tumor patients. However, the effect of …

Prostate cancer is a widespread malignancy characterized by a comparative ease of primary
diagnosis and difficulty in choosing the individualized course of treatment. Management of …

Background Squamous cell carcinoma of the head and neck (SCCHN) often contain highly
radioresistant hypoxic regions, nonetheless, radiotherapy is a common treatment modality …