Review covering up to mid-2021 The structure of polyketide and non-ribosomal peptide
natural products is strongly influenced by how they are released from their biosynthetic …

Covering: up to 2018 β-Lactones are strained rings that are useful organic synthons and
pharmaceutical warheads. Over 30 core scaffolds of β-lactone natural products have been …

The function of a protein is strongly dependent on its structure. During evolution, proteins
acquire new functions through mutations in the amino-acid sequence. Given the advance in …

Highlights•Many clinical antibiotics are natural products produced by thiotemplate-based
assembly line biosynthetic pathways.•Assembly line pathways provide an opportunity for …

Nonribosomal peptide synthetases produce diverse natural products using a multidomain
architecture where the growing peptide, attached to an integrated carrier domain, is …

Polyketides such as the antibiotic erythromycin or the immunosuppressant rapamycin, and
non-ribosomal peptides, such as the antibiotics penicillin or vancomycin, are important …

There is significant interest in diversifying the structures of polyketides to create new
analogues of these bioactive molecules. This has traditionally been done by focusing on …

Medium-ring lactones are synthetically challenging due to unfavorable energetics involved
in cyclization. We have discovered a thioesterase enzyme DcsB, from the decarestrictine C1 …

Emerging antibiotic resistance requires continual improvement in the arsenal of
antimicrobial drugs, especially the critical macrolide antibiotics. Formation of the …

Polyketides serve as rich source of therapeutically relevant drug leads. The manipulation of
polyketide synthases (PKSs) for generating derivatives with improved activities usually …