The importance of sulfur-containing motifs in drug design and discovery
Introduction Sulfur-containing functional groups are privileged motifs that occur in various
pharmacologically effective substances and several natural products. Various functionalities …
pharmacologically effective substances and several natural products. Various functionalities …
Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells
Background Glioblastoma (GBM) is an aggressive brain cancer associated with poor
prognosis, intrinsic heterogeneity, plasticity, and therapy resistance. In some GBMs, cell …
prognosis, intrinsic heterogeneity, plasticity, and therapy resistance. In some GBMs, cell …
Tracking Inhibition of Human Small C-Terminal Domain Phosphatase 1 Using 193 nm Ultraviolet Photodissociation Mass Spectrometry
Working in tandem with kinases via a dynamic interplay of phosphorylation and
dephosphorylation of proteins, phosphatases regulate many cellular processes and thus …
dephosphorylation of proteins, phosphatases regulate many cellular processes and thus …
[HTML][HTML] KIF15 promotes human glioblastoma progression under the synergistic transactivation of REST and P300
W Yu, S Han, S Hu, L Ru, C Hua, G Xue… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Glioblastoma (GBM) is highly invasive and lethal. The failure to cure GBM highlights the
necessity of developing more effective targeted therapeutic strategies. KIF15 is a motor …
necessity of developing more effective targeted therapeutic strategies. KIF15 is a motor …
Identification of Inhibitors of the Disease-Associated Protein Phosphatase Scp1 Using Antibody Mimetic Molecules
T Kobayashi, K Yamazaki, J Shinada… - International Journal of …, 2024 - mdpi.com
Protein phosphorylation is a prevalent translational modification, and its dysregulation has
been implicated in various diseases, including cancer. Despite its significance, there is a …
been implicated in various diseases, including cancer. Despite its significance, there is a …