Coordinating cell growth with nutrient availability is critical for cell survival. The evolutionarily
conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in …

The yeast Saccharomyces cerevisiae has been a favorite organism for pioneering studies
on nutrient-sensing and signaling mechanisms. Many specific nutrient responses have been …

Ever since the beginning of biochemical analysis, yeast has been a pioneering model for
studying the regulation of eukaryotic metabolism. During the last three decades, the …

For organisms to coordinate their growth and development with nutrient availability, they
must be able to sense nutrient levels in their environment. Here, we review select nutrient …

Glutamate occupies a central position in amino acid metabolism in plants. The acidic amino
acid is formed by the action of glutamate synthase, utilizing glutamine and 2-oxoglutarate …

Understanding how gene expression programs are controlled requires identifying regulatory
relationships between transcription factors and target genes. Gene regulatory networks are …

Glucose, the most abundant monosaccharide in nature, is the principal carbon and energy
source for nearly all cells. The first, and rate-limiting, step of glucose metabolism is its …

Recent research shows that signals derived from nitrate are involved in triggering
widespread changes in gene expression, resulting in a reprogramming of nitrogen and …

Yeast cells sense the amount and quality of external nutrients through multiple
interconnected signaling networks, which allow them to adjust their metabolism …

Interactions between bacterial and fungal cells shape many polymicrobial communities.
Bacteria elaborate diverse strategies to interact and compete with other organisms …