Oxidative stress (OS) has the ability to damage different molecules and cellular structures,
altering the correct function of organs and systems. OS accumulates in the body by …

The POLG gene encodes the mitochondrial DNA polymerase that is responsible for
replication of the mitochondrial genome. Mutations in POLG can cause early childhood …

Constitutive heterochromatin is responsible for genome repression of DNA enriched in
repetitive sequences, telomeres, and centromeres. During physiological and pathological …

High-throughput methods are powerful tools to develop predictive models for assessing
drug-induced liver injury (DILI). However, the development of predictive models requires a …

According to the WHO, 38 million individuals were living with human immunodeficiency virus
(HIV), 25.4 million of which were using antiretroviral therapy (ART) at the end of 2019 …

Antiretroviral therapy has changed human immunodeficiency virus (HIV) infection from a
near-certainly fatal illness to one that can be managed chronically. More patients are taking …

Hepatitis C virus (HCV) is a global health problem requiring novel approaches for effective
treatment of this disease. The HCV NS5B polymerase has been demonstrated to be a viable …

Medications are a common cause of AKI, especially for patients admitted to hospital wards
and the intensive care unit. Although drug-related kidney injury occurs through different …

Tenofovir is an acyclic nucleotide analogue reverse‐transcriptase inhibitor structurally
similar to the nephrotoxic drugs adefovir and cidofovir. Tenofovir is widely used to treat HIV …

To develop and validate a practical, in vitro, cell-based model to assess human
hepatotoxicity potential of drugs, we used the new technology of high content screening …