Modeling physiological events in 2D vs. 3D cell culture

K Duval, H Grover, LH Han, Y Mou… - …, 2017 - journals.physiology.org
Cell culture has become an indispensable tool to help uncover fundamental biophysical and
biomolecular mechanisms by which cells assemble into tissues and organs, how these …

Biological processing in oscillatory baffled reactors: operation, advantages and potential

MSR Abbott, AP Harvey, GV Perez… - Interface …, 2013 - royalsocietypublishing.org
The development of efficient and commercially viable bioprocesses is essential for reducing
the need for fossil-derived products. Increasingly, pharmaceuticals, fuel, health products and …

Oscillatory flow reactors (OFRs) for continuous manufacturing and crystallization

T McGlone, NEB Briggs, CA Clark… - … Process Research & …, 2015 - ACS Publications
Continuous crystallization is an attractive approach for the delivery of consistent particles
with specified critical quality attributes (CQAs), which are attracting increased interest for the …

An industrial perspective on bioreactor scale‐down: what we can learn from combined large‐scale bioprocess and model fluid studies

H Noorman - Biotechnology journal, 2011 - Wiley Online Library
For industrial bioreactor design, operation, control and optimization, the scale‐down
approach is often advocated to efficiently generate data on a small scale, and effectively …

Rapid process development using oscillatory baffled mesoreactors–A state-of-the-art review

JR McDonough, AN Phan, AP Harvey - Chemical Engineering Journal, 2015 - Elsevier
The mesoscale oscillatory baffled reactor (meso-OBR) is a novel technology for reaction
engineering and screening applications. The meso-OBR exhibits high degrees of plug flow …

A predictive high‐throughput scale‐down model of monoclonal antibody production in CHO cells

R Legmann, HB Schreyer, RG Combs… - Biotechnology and …, 2009 - Wiley Online Library
Multi‐factorial experimentation is essential in understanding the link between mammalian
cell culture conditions and the glycoprotein product of any biomanufacturing process. This …

Design, performance characterization and applications of continuous oscillatory baffled reactors

M Avila, B Kawas, DF Fletcher, M Poux… - … and Processing-Process …, 2022 - Elsevier
The continuous oscillatory baffled reactor (OBR) is a particular type of tubular reactor, which
has drawn increasing attention over the past few decades due to the benefits it provides in …

Numerical study of the flow pattern and heat transfer enhancement in oscillatory baffled reactors with helical coil inserts

JP Solano, R Herrero, S Espín, AN Phan… - … Research and Design, 2012 - Elsevier
Oscillatory baffled reactors (OBRs) are a means of process intensification as they allow
processes with long residence time to be converted from batch to continuous processing …

O2 mass transfer in an oscillatory flow reactor provided with smooth periodic constrictions. Individual characterization of kL and a

A Ferreira, JA Teixeira, F Rocha - Chemical Engineering Journal, 2015 - Elsevier
In the present work the superficial gas velocities (u G) and the oscillatory conditions
(frequency and amplitude) effects on the gas–liquid mass transfer process in a novel …

Characterising flow with continuous aeration in an oscillatory baffle flow reactor using residence time distribution

R Cox, K Salonitis, SA Impey, E Rebrov - Reaction Chemistry & …, 2023 - pubs.rsc.org
Multi-phase flow occurs in many reactions with gas, an integral part of the reaction. This
study assesses the synergistic impact of continuous aeration and velocity ratio on mixing …