Modeling physiological events in 2D vs. 3D cell culture
Cell culture has become an indispensable tool to help uncover fundamental biophysical and
biomolecular mechanisms by which cells assemble into tissues and organs, how these …
biomolecular mechanisms by which cells assemble into tissues and organs, how these …
Biological processing in oscillatory baffled reactors: operation, advantages and potential
MSR Abbott, AP Harvey, GV Perez… - Interface …, 2013 - royalsocietypublishing.org
The development of efficient and commercially viable bioprocesses is essential for reducing
the need for fossil-derived products. Increasingly, pharmaceuticals, fuel, health products and …
the need for fossil-derived products. Increasingly, pharmaceuticals, fuel, health products and …
Oscillatory flow reactors (OFRs) for continuous manufacturing and crystallization
T McGlone, NEB Briggs, CA Clark… - … Process Research & …, 2015 - ACS Publications
Continuous crystallization is an attractive approach for the delivery of consistent particles
with specified critical quality attributes (CQAs), which are attracting increased interest for the …
with specified critical quality attributes (CQAs), which are attracting increased interest for the …
An industrial perspective on bioreactor scale‐down: what we can learn from combined large‐scale bioprocess and model fluid studies
H Noorman - Biotechnology journal, 2011 - Wiley Online Library
For industrial bioreactor design, operation, control and optimization, the scale‐down
approach is often advocated to efficiently generate data on a small scale, and effectively …
approach is often advocated to efficiently generate data on a small scale, and effectively …
Rapid process development using oscillatory baffled mesoreactors–A state-of-the-art review
The mesoscale oscillatory baffled reactor (meso-OBR) is a novel technology for reaction
engineering and screening applications. The meso-OBR exhibits high degrees of plug flow …
engineering and screening applications. The meso-OBR exhibits high degrees of plug flow …
A predictive high‐throughput scale‐down model of monoclonal antibody production in CHO cells
R Legmann, HB Schreyer, RG Combs… - Biotechnology and …, 2009 - Wiley Online Library
Multi‐factorial experimentation is essential in understanding the link between mammalian
cell culture conditions and the glycoprotein product of any biomanufacturing process. This …
cell culture conditions and the glycoprotein product of any biomanufacturing process. This …
Design, performance characterization and applications of continuous oscillatory baffled reactors
M Avila, B Kawas, DF Fletcher, M Poux… - … and Processing-Process …, 2022 - Elsevier
The continuous oscillatory baffled reactor (OBR) is a particular type of tubular reactor, which
has drawn increasing attention over the past few decades due to the benefits it provides in …
has drawn increasing attention over the past few decades due to the benefits it provides in …
Numerical study of the flow pattern and heat transfer enhancement in oscillatory baffled reactors with helical coil inserts
Oscillatory baffled reactors (OBRs) are a means of process intensification as they allow
processes with long residence time to be converted from batch to continuous processing …
processes with long residence time to be converted from batch to continuous processing …
O2 mass transfer in an oscillatory flow reactor provided with smooth periodic constrictions. Individual characterization of kL and a
In the present work the superficial gas velocities (u G) and the oscillatory conditions
(frequency and amplitude) effects on the gas–liquid mass transfer process in a novel …
(frequency and amplitude) effects on the gas–liquid mass transfer process in a novel …
Characterising flow with continuous aeration in an oscillatory baffle flow reactor using residence time distribution
R Cox, K Salonitis, SA Impey, E Rebrov - Reaction Chemistry & …, 2023 - pubs.rsc.org
Multi-phase flow occurs in many reactions with gas, an integral part of the reaction. This
study assesses the synergistic impact of continuous aeration and velocity ratio on mixing …
study assesses the synergistic impact of continuous aeration and velocity ratio on mixing …