Post-transplant diabetes mellitus: causes, treatment, and impact on outcomes
V Shivaswamy, B Boerner, J Larsen - Endocrine reviews, 2016 - academic.oup.com
Post-transplant diabetes mellitus (PTDM) is a frequent consequence of solid organ
transplantation. PTDM has been associated with greater mortality and increased infections …
transplantation. PTDM has been associated with greater mortality and increased infections …
Molecules great and small: the complement system
DR Mathern, PS Heeger - … Journal of the American Society of …, 2015 - journals.lww.com
The complement cascade, traditionally considered an effector arm of innate immunity
required for host defense against pathogens, is now recognized as a crucial pathogenic …
required for host defense against pathogens, is now recognized as a crucial pathogenic …
A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation
Using meta-analysis of eight independent transplant datasets (236 graft biopsy samples)
from four organs, we identified a common rejection module (CRM) consisting of 11 genes …
from four organs, we identified a common rejection module (CRM) consisting of 11 genes …
The role of complement in the early immune response to transplantation
SH Sacks, W Zhou - Nature Reviews Immunology, 2012 - nature.com
The complement system is a key element of the innate immune system, and the production
of complement components can be divided into central (hepatic) and peripheral …
of complement components can be divided into central (hepatic) and peripheral …
[HTML][HTML] Delayed kidney graft function: from mechanism to translation
B Schröppel, C Legendre - Kidney international, 2014 - Elsevier
In as many as 50% of cases the immediate post-kidney transplant course is complicated by
delayed graft function that is most commonly related to ischemia and reperfusion injury. In …
delayed graft function that is most commonly related to ischemia and reperfusion injury. In …
Clinical role of the renal transplant biopsy
WW Williams, D Taheri, N Tolkoff-Rubin… - Nature Reviews …, 2012 - nature.com
Percutaneous needle core biopsy is the definitive procedure by which essential diagnostic
and prognostic information on acute and chronic renal allograft dysfunction is obtained. The …
and prognostic information on acute and chronic renal allograft dysfunction is obtained. The …
The role of complement in the pathogenesis of renal ischemia-reperfusion injury and fibrosis
JS Danobeitia, A Djamali, LA Fernandez - Fibrogenesis & tissue repair, 2014 - Springer
The complement system is a major component of innate immunity and has been commonly
identified as a central element in host defense, clearance of immune complexes, and tissue …
identified as a central element in host defense, clearance of immune complexes, and tissue …
Hypoxia and complement-and-coagulation pathways in the deceased organ donor as the major target for intervention to improve renal allograft outcome
J Damman, VW Bloks, MR Daha, PJ van der Most… - …, 2015 - journals.lww.com
Background In the last few decades, strategies to improve allograft survival after kidney
transplantation have been directed to recipient-dependent mechanisms of renal injury. In …
transplantation have been directed to recipient-dependent mechanisms of renal injury. In …
Local renal complement C3 induction by donor brain death is associated with reduced renal allograft function after transplantation
J Damman, WN Nijboer, TA Schuurs… - Nephrology Dialysis …, 2011 - academic.oup.com
Background. Kidneys derived from brain-dead donors have inferior outcomes after
transplantation compared to kidneys from living donors. Strikingly, early and profound serum …
transplantation compared to kidneys from living donors. Strikingly, early and profound serum …
[HTML][HTML] Gene expression in biopsies of acute rejection and interstitial fibrosis/tubular atrophy reveals highly shared mechanisms that correlate with worse long‐term …
Interstitial fibrosis and tubular atrophy (IFTA) is found in approximately 25% of 1‐year
biopsies posttransplant. It is known that IFTA correlates with decreased graft survival when …
biopsies posttransplant. It is known that IFTA correlates with decreased graft survival when …