Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's
expressed genes and then transport and display this antigenic information on the cell …

Abstract COVID-19, caused by SARS-CoV-2 infection, is mild to moderate in the majority of
previously healthy individuals, but can cause life-threatening disease or persistent …

Single-cell technologies have enabled the characterization of the tumour microenvironment
at unprecedented depth and have revealed vast cellular diversity among tumour cells and …

Advances in molecular profiling have opened up the possibility to map the expression of
genes in cells, tissues, and organs in the human body. Here, we combined single-cell …

The clinical use of molecular targeted therapy is rapidly evolving but has primarily focused
on genomic alterations. Transcriptomic analysis offers an opportunity to dissect the …

Liquid biopsies that measure circulating cell-free RNA (cfRNA) offer an opportunity to study
the development of pregnancy-related complications in a non-invasive manner and to …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is typically very
mild and often asymptomatic in children. A complication is the rare multisystem inflammatory …

Autologous chimeric antigen receptor (CAR) T cell therapies targeting CD19 have high
efficacy in large B cell lymphomas (LBCLs), but long-term remissions are observed in less …

A key challenge in analyzing single cell RNA-sequencing data is the large number of false
zeros, where genes actually expressed in a given cell are incorrectly measured as …

The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and
society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific …