In its early stages, symptoms of chronic kidney disease (CKD) are usually not apparent.
Significant reduction of the kidney function is the first obvious sign of disease. If diagnosed …

Proteinuria is the hallmark of diabetic kidney disease (DKD) and is an independent risk
factor for both renal disease progression, and cardiovascular disease. Although the …

Because of its availability, ease of collection, and correlation with physiology and pathology,
urine is an attractive source for clinical proteomics/peptidomics. However, the lack of …

Background: Urinary excretion of albumin indicates kidney damage and is recognized as a
risk factor for progression of kidney disease and cardiovascular disease. The role of urinary …

Urine has become one of the most attractive biofluids in clinical proteomics as it can be
obtained non-invasively in large quantities and is stable compared with other biofluids. The …

Background Oxidative damage results in protein modification, and is observed in numerous
diseases. Human serum albumin (HSA), the most abundant circulating protein in the …

Introduction: Urine is a highly desirable biospecimen for biomarker analysis because it can
be collected recurrently by non-invasive techniques, in relatively large volumes. Urine …

Noninvasive diagnosis of kidney diseases and assessment of the prognosis are still
challenges in clinical nephrology. Definition of biomarkers on the basis of proteome …

The aim of this manuscript is to initiate a constructive discussion about the definition of
clinical proteomics, study requirements, pitfalls and (potential) use. Furthermore, we hope to …

For centuries, physicians have attempted to use the urine for noninvasive assessment of
disease. Today, urinalysis, in particular the measurement of proteinuria, underpins the …