The quality and maturation of an oocyte not only play decisive roles in fertilization and
embryo success, but also have long-term impacts on the later growth and development of …

In human female primordial germ cells, the transition from mitosis to meiosis begins from the
fetal stage. In germ cells, meiosis is arrested at the diplotene stage of prophase in meiosis I …

Polycystic ovary syndrome (PCOS) is a complex endocrinopathy associated with
subfertility/infertility and pregnancy complications. Most PCOS women opt for assisted …

Introduction: Oocyte quality and fertility decline with advanced maternal age. During
maturation within the ovarian follicle, the oocyte relies on the associated somatic cells …

During oogenesis, oocytes arrest at meiotic prophase I to acquire competencies for
resuming meiosis, fertilization, and early embryonic development. Following this arrested …

Vitamin D3 plays a crucial role in female reproduction. As research progresses, the
mechanisms of action of vitamin D3 on follicular development have been widely discussed …

The search for simple morphological predictors of oocyte quality is an important task for
assisted reproduction technologies (ARTs). One such predictor may be the morphology of …

Germ cell division and differentiation require intimate contact and interaction with the
surrounding somatic cells. Luteinizing hormone (LH) triggers epidermal growth factor (EGF) …

Meiotic maturation and cumulus expansion are essential for the generation of a
developmentally competent gamete, and both processes can be recapitulated in vitro. We …

STUDY QUESTION Can in vitro maturation (IVM) and developmental competence of human
oocytes be improved by co-culture with ovarian support cells (OSCs) derived from human …