Autophagy, a conserved catabolic process, plays an immensely significant role in a variety
of diseases. However, whether it imparts a protective function in diseases remains …

The lysosome plays a pivotal role between catabolic and anabolic processes as the nexus
for signalling pathways responsive to a variety of factors, such as growth, nutrient …

Mitochondrial quality control is critical for cardiac homeostasis as these organelles are
responsible for generating most of the energy needed to sustain contraction. Dysfunctional …

Maintaining mitochondrial health is emerging as a keystone in aging and associated
diseases. The selective degradation of mitochondria by mitophagy is of particular …

Background Danon disease is a rare, X-linked, monogenic cardiomyopathy caused by
mutations in the lysosomal-associated membrane 2 gene (LAMP2), which encodes the …

Background Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have
emerged as a powerful tool for disease modeling, though their immature nature currently …

Mutations in lysosomal-associated membrane protein 2 (LAMP-2) gene are associated with
Danon disease, which often leads to cardiomyopathy/heart failure through poorly defined …

Background Danon disease (DD) is a rare X-linked autophagic vacuolar myopathy,
characterized by high penetrance and severe cardiomyopathy. Because of its rarity, the …

Human-induced pluripotent stem cells (hiPSC) can be differentiated to cardiomyocytes at
high efficiency and are increasingly used to study cardiac disease in a human context. This …

Sarcopenia is the loss of both muscle mass and function with age. Although the molecular
underpinnings of sarcopenia are not fully understood, numerous pathways are implicated …