Chronic kidney disease (CKD) is a leading cause of global morbidity and mortality and is
independently associated with cardiovascular disease. The mainstay of treatment for CKD is …

Abstract SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the etiological
agent of COVID-19 (coronavirus disease 2019) and the cause of the current pandemic …

The apelin/apelin receptor (ApelinR) signal transduction pathway exerts essential biological
roles, particularly in the cardiovascular system. Disturbances in the apelin/ApelinR axis are …

Background: Coronavirus disease 19 (COVID-19) can develop into a severe respiratory
syndrome that results in up to 40% mortality. Acute lung inflammatory edema is a major …

Abstract SARS-CoV-2, the pathogenic agent of COVID-19, employs angiotensin converting
enzyme-2 (ACE2) as its cell entry receptor. Clinical data reveal that in severe COVID-19 …

The apelinergic pathway has been generating increasing interest in the past few years for its
potential as a therapeutic target in several conditions associated with the cardiovascular and …

Over the past several decades, liposomes have been extensively developed and used for
various clinical applications such as in pharmaceutical, cosmetic, and dietetic fields, due to …

Apelin, a (neuro) vasoactive peptide, plays a prominent role in controlling body fluid
homeostasis and cardiovascular functions. Experimental data performed in rodents have …

The apelinergic system is widely expressed and acts through autocrine and paracrine
signaling to exert protective effects, including vasodilatory, metabolic, and inotropic effects …

Diabetic foot ulcer (DFU) is a serious complication of diabetes. Elabela (ELA), a ligand of
apelin receptor (APJ), was shown to promote angiogenesis and suppress inflammation. This …