The 1918 Spanish influenza pandemic was one of the deadliest infectious disease events in
recorded history, resulting in approximately 50–100 million deaths worldwide. The origins of …

Reverse genetic systems are widely used to engineer recombinant viruses with desired
mutations. In response to the COVID-19 pandemic, four types of reverse genetic systems …

The current COVID-19 pandemic is caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). We demonstrate that despite the large size of the viral RNA …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as the
causative agent of coronavirus disease 2019 (COVID-19). Although multiple mutations have …

Summary The Asian lineage of Zika virus (ZIKV) has recently caused epidemics and severe
disease. Unraveling the mechanisms causing increased viral transmissibility and disease …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF6 is an antagonist of
interferon (IFN)-mediated antiviral signaling, achieved through the prevention of STAT1 …

Flaviviruses, including Zika virus (ZIKV), utilise host mRNA degradation machinery to
produce subgenomic flaviviral RNA (sfRNA). In mammalian hosts, this noncoding RNA …

The study of flaviviruses, which cause some of the most important emerging tropical and sub-
tropical human arbovirus diseases, has greatly benefited from the use of reverse genetic …

Many patients with severe COVID-19 suffer from pneumonia and the elucidation of the
mechanisms underlying the development of this severe condition is important. The in vivo …

An arthropod-borne virus, Zika virus (ZIKV), has recently emerged as a major human
pathogen. Associated with complications during perinatal development and Guillain-Barré …