The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

The direct C3-functionalization of quinoxalin-2 (1H)-ones via C–H bond activation has
recently attracted considerable attention, due to their diverse biological activities and …

Activation of glutamate receptors can trigger the death of neurons and some types of glial
cells, particularly when the cells are coincidentally subjected to adverse conditions such as …

Herein, a green and efficient metal-free cross-dehydrogenative coupling (CDC) for the direct
para-C–H heteroarylation of anilines with quinoxalinones has been described. This reaction …

Herein, a novel method for the gram-scale synthesis of (E)-quinoxalinone oximes through a
multicomponent reaction under mild conditions is described. Such a transformation was …

The first example of oxidative C–H fluoroalkoxylation of quinoxalinones with fluoroalkyl
alcohols under transition-metal and solvent-free conditions is described. This approach …

Primary and/or secondary glial cell death can cause and/or aggravate human diseases of
the central nervous system (CNS). Like neurons, glial cells are vulnerable to glutamate …

A convenient and practical metal-free visible-light-promoted method to synthesize 3-
oxyalkylated quinoxalin-2 (1 H)-ones was developed at room temperature. The present …

A metal-free cross-dehydrogenative coupling between quinoxalinones (sp2 C–H) and
amines (N–H) in the presence of catalytic iodine is reported. The reaction yields 3 …

White matter of the brain and spinal cord is susceptible to anoxia, ischemia, trauma and
autoimmune attack. Irreversible injury to this tissue can have serious consequences for the …