Cockayne syndrome (CS) is a disorder characterized by a variety of clinical features
including cachectic dwarfism, severe neurological manifestations including microcephaly …

Cell division and organismal development are exquisitely orchestrated and regulated
processes. The dysregulation of the molecular mechanisms underlying these processes …

The small intestinal epithelium self-renews every four or five days. Intestinal stem cells
(Lgr5+ crypt base columnar cells (CBCs)) sustain this renewal and reside between …

Significance: The p53 tumor suppressor has been dubbed the “guardian of genome”
because of its various roles in the response to DNA damage such as DNA damage repair …

Age and DNA repair deficiencies are strong risk factors for developing cancer. This is
reflected in the comorbidity of cancer with premature aging diseases associated with DNA …

Reactive oxygen species (ROS) play important roles in aging, inflammation, and cancer.
Mitochondria are an important source of ROS; however, the spatiotemporal ROS events …

Accumulation of mutations in mitochondrial DNA leads to the development of severe,
currently untreatable diseases. The contribution of these mutations to aging and progress of …

Reactive oxygen and nitrogen species damage cellular macromolecules including DNA.
Cells have a robust base excision repair pathway to deal with this damage in both nuclear …

Abstract Reactive Oxygen Species (ROS) derived from mitochondrial respiration are
frequently cited as a major source of chromosomal DNA mutations that contribute to cancer …

Cockayne syndrome is a neurodegenerative accelerated aging disorder caused by
mutations in the CSA or CSB genes. Although the pathogenesis of Cockayne syndrome has …