Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a
high morbidity additionally, CRC patients may develop liver metastasis, which is the major …

Current immunotherapies yield remarkable clinical outcomes by boosting the power of host
immunity in cancer cell elimination and viral clearance. However, after prolonged antigen …

The number of molecularly stratified treatment options available to patients with colorectal
cancer (CRC) is increasing, with a parallel rise in the use of biomarkers to guide …

Colorectal cancer (CRC) patients with liver metastases usually obtain less benefit from
immunotherapy, and the underlying mechanisms remain understudied. Here, we identify …

Simple Summary Patients with chronic lymphocytic leukemia (CLL), the most frequent B cell
malignancy in western countries, develop a progressive immunosuppression, leading to …

Simple Summary Spine metastases are a common life-threatening complication of
advanced-stage malignancies and often result in poor prognosis. Symptomatic spine …

Immunotherapy is a new pillar of cancer therapy that provides novel opportunities to treat
solid tumors. In this context, the development of new drugs targeting immune checkpoints is …

ABSTRACT A disease of more than 39.6 million people worldwide, HIV-1 infection has no
curative therapy. To date, one man has achieved a sterile cure, with millions more hoping to …

Background & Aims Cholangiocarcinoma is an aggressive hepatobiliary malignancy
originating from biliary tract epithelium. Whether cholangiocarcinoma is responsive to …

The use of cytokines for immunotherapy shows clinical efficacy but is frequently
accompanied by severe adverse events caused by excessive and systemic immune …