Mammalian hibernation is characterized by profound reductions in metabolism, oxygen
consumption and heart rate. As a result, the animal enters a state of suspended animation …

During winter hibernation, small mammals fall into long periods of deep cold torpor where
metabolic rate is suppressed by> 90% and core body temperature can fall to near 0 C …

Diapause, the dormancy common to overwintering insects, evokes a unique pattern of gene
expression. In the flesh fly, most, but not all, of the fly's heat shock proteins (Hsps) are up …

Reactive oxygen species (ROS), inevitable byproducts of aerobic metabolism, are known to
cause oxidative damage to cells and molecules. This, in turn, is widely accepted as a pivotal …

Chaperone proteins have crucial roles to play in all animal species and are involved in
mediating both the folding of newly synthesized peptides into their mature conformation, the …

Terrestrially hibernating reptiles that live in seasonally cold climates need effective
strategies of cold hardiness to survive the winter. Use of thermally buffered hibernacula is …

During hibernation, animals cycle between periods of torpor, during which body temperature
(Tb) and metabolic rate (MR) are suppressed for days, and interbout euthermia (IBE), during …

Hibernation in Arctic ground squirrels (AGS), Spermophilus parryii, is characterized by a
profound decrease in oxygen consumption and metabolic demand during torpor that is …

Freshwater turtles of the Trachemys and Chrysemys genera are champion facultative
anaerobes able to survive for several months without oxygen during winter hibernation in …

The molecular basis for adaptations to extreme environments can now be understood by
interrogating the ever‐increasing number of sequenced genomes. Mammals such as …