This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive
impairment and affects all levels of the brain's vasculature. Features include diverse …

G protein-coupled receptors (GPCRs) are critical regulators of human physiology and make
up the largest single class of therapeutic drug targets. Although GPCRs regulate highly …

Incorporating mechanical cues into cellular responses allows us to experience our direct
environment. Specialized cells can perceive and discriminate between different physical …

Resistance arteries and downstream arterioles in the peripheral microcirculation contribute
substantially to peripheral vascular resistance, control of blood pressure, the distribution of …

G-protein coupled receptors (GPCRs) are versatile cellular sensors for chemical stimuli, but
also serve as mechanosensors involved in various (patho) physiological settings like …

Arteriolar smooth muscle cells (SMCs) and capillary pericytes dynamically regulate blood
flow in the central nervous system in the face of fluctuating perfusion pressures. Pressure …

Blood vessels are subjected to mechanical loads of pressure and flow, inducing smooth
muscle circumferential and endothelial shear stresses. The perception and response of …

Background: Preeclampsia is a syndrome of high blood pressure (BP) with end organ
damage in late pregnancy that is associated with high circulating soluble VEGF receptor …

Arterioles in the peripheral microcirculation regulate blood flow to and within tissues and
organs, control capillary blood pressure and microvascular fluid exchange, govern …