Acute kidney injury (AKI) following platinum-based chemotherapeutics is a frequently
reported serious side-effect. However, there are no approved biomarkers that can properly …

Aims Nephrotoxicity is the hallmark of anti-neoplastic drug metabolism that causes oxidative
stress. External chemical agents and prescription drugs release copious amounts of free …

Purpose Cisplatin-associated acute kidney injury (C-AKI) is common. We sought to develop
and validate a predictive model for C-AKI after the first course of cisplatin. Methods Clinical …

Four steroidal saponins, spirostan-25 (27)-ene-1β, 3α-diol-1-O-[α-L-rhamnopyranosyl-(1→
2)-α-L-rhamnopyranoside](fruticoside M)(6), 5α-spirost-25 (27)-ene-1β, 3β-diol-1-O-α-L …

Nephrotoxicity is defining as rapid deterioration in the kidney function due to toxic effect of
medications and chemicals. There are various forms, and some drugs may affect renal …

Drug-induced nephrotoxicity is still a significant obstacle in pharmacotherapy of various
diseases and it accounts for around 25% of serious side-effects reported after drug …

Objective In addition to oxidative stress, inflammation and apoptosis have an important role
in the pathogenesis of cisplatin-induced kidney damage. This study aimed to investigate the …

Acute kidney injury (AKI), either of pre-renal, renal or post-renal origin, is an important
complication in cancer patients, resulting in worse prognosis, withdrawal from effective …

Cancer chemotherapy is still a serious challenge. Chemo-resistance and destructive side
effects of chemotherapy drugs are the most critical limitations of chemotherapy. Chemo …

Cisplatin (CDDP) is a highly effective antineoplastic agent, widely used in the treatment of
various malignant tumors. However, its major problems are side effects associated to …