Background Imatinib (IM), a tyrosine kinase inhibitor (TKI), has markedly improved the
survival and life quality of chronic myeloid leukemia (CML) patients. However, the lack of …

Small nucleotide variants in non-coding regions of the genome can alter transcriptional
regulation, leading to changes in gene expression which can activate oncogenic gene …

Triple-negative breast cancer (TNBC) accounts for∼ 20% of all breast cancer (BC) cases.
The management of TNBC represents a challenge due to its worse prognosis, heterogeneity …

Abstract Regulation of Aberrant Protein Production (RAPP) is a protein quality control in
mammalian cells. RAPP degrades mRNAs of nascent proteins not able to associate with …

Despite its significant overexpression in several malignant neoplasms, the expression of
RPS27 in the central nervous system (CNS) is widely unknown. We identified the cell types …

Objectives: Abdominal aortic aneurysms (AAAs) are associated with high mortality rates. The
genes and pathways linked with AAA remain poorly understood. This study aimed to identify …

Non-small cell lung cancer is a major lethal subtype of epithelial lung cancer, with high
morbidity and mortality. The single-cell sequencing technique plays a key role in exploring …

Evolution from a benign naevus to a melanoma results principally from the stepwise
accumulation of mutations. We used a custom next generation sequencing (NGS) panel …

Background. The expression of ribosomal protein S27 (RPS27) is upregulated in multiple
human malignancies. In thyroid cancer, the expression of RPS27 is associated with patient …

Basal cell carcinoma (BCC) of the skin is the most common cancer in humans, characterized
by the highest mutation rate among cancers, and is mostly driven by mutations in genes …