Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific
metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions …

Due to their superior tolerability and efficacy, β-lactams are the most potent and prescribed
class of antibiotics in the clinic. The emergence of resistance to those antibiotics, mainly due …

Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Staphylococcus aureus is a member of the human commensal microflora that exists,
apparently benignly, at multiple sites on the host. However, as an opportunist pathogen it …

S100A8 and S100A9 (also known as MRP8 and MRP14, respectively) are Ca2+ binding
proteins belonging to the S100 family. They often exist in the form of heterodimer, while …

Staphylococcus aureus is a Gram-positive opportunistic pathogen that has evolved a
complex regulatory network to control virulence. One of the main functions of this …

Modern medicine is threatened by the global rise of antibiotic resistance, especially among
Gram-negative bacteria. Metallo-β-lactamase (MBL) enzymes are a particular concern and …

Acinetobacter baumannii is undoubtedly one of the most successful pathogens responsible
for hospital-acquired nosocomial infections in the modern healthcare system. Due to the …

Micronutrient homeostasis is a key factor in maintaining a healthy immune system. Zinc is an
essential micronutrient that is involved in the regulation of the innate and adaptive immune …

Manganese (Mn) is essential for many physiological processes, but its functions in innate
immunity remain undefined. Here, we found that Mn 2+ was required for the host defense …