Mesenchymal stem cells and exosome therapy for COVID-19: current status and future perspective

A Gupta, S Kashte, M Gupta, HC Rodriguez… - Human cell, 2020 - Springer
Acute respiratory distress syndrome (ARDS) is the main cause for the COVID-19 infection-
related morbidity and mortality. Recent clinical evidences suggest increased level of …

The role of Interleukin 1 receptor antagonist in mesenchymal stem cell‐based tissue repair and regeneration

CR Harrell, BS Markovic, C Fellabaum… - Biofactors, 2020 - Wiley Online Library
Abstract Interleukin (IL)‐1 receptor antagonist (IL‐1Ra), a naturally occurring antagonist of IL‐
1α/IL‐1β signaling pathways, has been attributed to the immunosuppressive effects of …

Efficacy and safety of intravenous mesenchymal stem cells for ischemic stroke

JW Chung, WH Chang, OY Bang, GJ Moon, SJ Kim… - Neurology, 2021 - AAN Enterprises
Objective To test whether autologous modified mesenchymal stem cells (MSCs) improve
recovery in patients with chronic major stroke. Methods In this prospective, open-label …

Novel insights into the treatment of SARS-CoV-2 infection: An overview of current clinical trials

F Oroojalian, A Haghbin, B Baradaran… - International Journal of …, 2020 - Elsevier
The emergence of the global pandemic caused by the novel SARS-CoV-2 virus has
motivated scientists to find a definitive treatment or a vaccine against it in the shortest …

Mesenchymal stem cell-derived exosomes exhibit promising potential for treating SARS-CoV-2-infected patients

A Raghav, ZA Khan, VK Upadhayay, P Tripathi… - Cells, 2021 - mdpi.com
The novel coronavirus severe acute respiratory syndrome-CoV-2 (SARS-CoV-2) is
responsible for COVID-19 infection. The COVID-19 pandemic represents one of the worst …

Pretreatment of UC-MSCs with IFN-α2 improves treatment of liver fibrosis by recruiting neutrophils

Y Xie, J Yao, M Yan, Y Lin, J Wei, H Wang… - Journal of Translational …, 2023 - Springer
Background The use of umbilical cord mesenchymal stem cells (UC-MSCs) is a burgeoning
method for the treatment of liver cirrhosis. However, the secretory phenotype and regulatory …

Therapeutic mechanisms of mesenchymal stem cells in acute respiratory distress syndrome reveal potentials for Covid-19 treatment

W Wang, W Lei, L Jiang, S Gao, S Hu, ZG Zhao… - Journal of translational …, 2021 - Springer
The mortality rate of critically ill patients with acute respiratory distress syndrome (ARDS) is
30.9% to 46.1%. The emergence of the coronavirus disease 2019 (Covid-19) has become a …

The inflammatory lung microenvironment; a key mediator in MSC licensing

H Dunbar, DJ Weiss, S Rolandsson Enes, JG Laffey… - Cells, 2021 - mdpi.com
Recent clinical trials of mesenchymal stromal cell (MSC) therapy for various inflammatory
conditions have highlighted the significant benefit to patients who respond to MSC …

[HTML][HTML] Mesenchymal stem cells as living anti-inflammatory therapy for COVID-19 related acute respiratory distress syndrome

F Lin, TE Ichim, S Pingle, LD Jones… - World journal of stem …, 2020 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19), a pandemic disease caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV2), is growing at an exponential rate …

Mesenchymal stem cells as a potential treatment for critically ill patients with coronavirus disease 2019

F Ji, L Li, Z Li, Y Jin, W Liu - Stem cells translational medicine, 2020 - academic.oup.com
To the Editor, We read with interest the article by Abraham and Krasnodembskaya regarding
mesenchymal stem cells (MSCs)-derived extracellular vesicles for the treatment of acute …