[HTML][HTML] Host and microbiome genome-wide association studies: current state and challenges
D Awany, I Allali, S Dalvie, S Hemmings… - Frontiers in …, 2019 - frontiersin.org
The involvement of the microbiome in health and disease is well established. Microbiome
genome-wide association studies (mGWAS) are used to elucidate the interaction of host …
genome-wide association studies (mGWAS) are used to elucidate the interaction of host …
Development of bioinformatics infrastructure for genomics research
Background Although pockets of bioinformatics excellence have developed in Africa,
generally, large-scale genomic data analysis has been limited by the availability of expertise …
generally, large-scale genomic data analysis has been limited by the availability of expertise …
Genetic modifiers of long‐term survival in sickle cell anemia
A Wonkam, ER Chimusa, K Mnika… - Clinical and …, 2020 - Wiley Online Library
Background Sickle cell anemia (SCA) is a clinically heterogeneous, monogenic disorder.
Medical care has less‐than‐optimal impact on clinical outcomes in SCA in Africa due to …
Medical care has less‐than‐optimal impact on clinical outcomes in SCA in Africa due to …
[HTML][HTML] Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospects
D Damena, A Denis, L Golassa, ER Chimusa - BMC medical genomics, 2019 - Springer
Background P. falciparum malaria has been recognized as one of the prominent
evolutionary selective forces of human genome that led to the emergence of multiple host …
evolutionary selective forces of human genome that led to the emergence of multiple host …
Biological networks for cancer candidate biomarkers discovery
Due to its extraordinary heterogeneity and complexity, cancer is often proposed as a model
case of a systems biology disease or network disease. There is a critical need of effective …
case of a systems biology disease or network disease. There is a critical need of effective …
[HTML][HTML] Whole genome sequencing reveals population diversity and variation in HIV-1 specific host genes
HIV infection continues to be a major global public health issue. The population
heterogeneity in susceptibility or resistance to HIV-1 and progression upon infection is …
heterogeneity in susceptibility or resistance to HIV-1 and progression upon infection is …
[HTML][HTML] Dissecting meta-analysis in GWAS era: Bayesian framework for gene/subnetwork-specific meta-analysis
ER Chimusa, J Defo - Frontiers in Genetics, 2022 - frontiersin.org
Over the past decades, advanced high-throughput technologies have continuously
contributed to genome-wide association studies (GWASs). GWAS meta-analysis has been …
contributed to genome-wide association studies (GWASs). GWAS meta-analysis has been …
[HTML][HTML] A post-GWAS analysis of predicted regulatory variants and tuberculosis susceptibility
Utilizing data from published tuberculosis (TB) genome-wide association studies (GWAS),
we use a bioinformatics pipeline to detect all polymorphisms in linkage disequilibrium (LD) …
we use a bioinformatics pipeline to detect all polymorphisms in linkage disequilibrium (LD) …
Post genome-wide association analysis: dissecting computational pathway/network-based approaches
Over thousands of genetic associations to diseases have been identified by genome-wide
association studies (GWASs), which conceptually is a single-marker-based approach. There …
association studies (GWASs), which conceptually is a single-marker-based approach. There …
From SNP to pathway-based GWAS meta-analysis: do current meta-analysis approaches resolve power and replication in genetic association studies?
J Defo, D Awany, R Ramesar - Briefings in Bioinformatics, 2023 - academic.oup.com
Genome-wide association studies (GWAS) have benefited greatly from enhanced high-
throughput technology in recent decades. GWAS meta-analysis has become increasingly …
throughput technology in recent decades. GWAS meta-analysis has become increasingly …