High altitude (hypobaric hypoxia) triggers several mechanisms to compensate for the
decrease in oxygen bioavailability. One of them is pulmonary artery vasoconstriction and its …

The calibrated application of limited-duration, cyclic, moderately intense hypoxia-
reoxygenation increases cardiac resistance to ischemia-reperfusion stress. These …

Increased life expectancy, attributed to improved access to healthcare and drug
development, has led to an increase in multimorbidity, a key contributor to polypharmacy …

Diabetes mellitus (DM) is a complex disease with alarming worldwide health implications
and high mortality rates, largely due to its complications such as cardiovascular disease …

Type 2 diabetes (T2D) substantially elevates the risk for heart failure, a major cause of
death. In advanced T2D, energy metabolism in the heart is disrupted; glucose metabolism is …

Background: Accumulating evidence suggested that bone marrow mesenchymal stem cells
(BMSCs) have therapeutic potential for diabetes and heart diseases. However, the effects of …

Mitochondria involve in the determination of ischemic neuronal cell fate through regulation
of apoptotic and necrotic cell death. Phosphatase and tensin homolog (PTEN) protein …

Kindlovits, Raquel, Alberto Mello da Silva Pereira, Ana Catarina Sousa, João Luís Viana,
and Vitor Hugo Teixeira. Effects of acute and chronic exercise in hypoxia on cardiovascular …

Background and aims Obstructive sleep apnea syndrome is a chronic disease associated
with intermittent hypoxia (IH) and is an important risk factor for cardiovascular disease …

Background: In chronic hypoxia (CH) and short-term chronic intermittent hypoxia (CIH)
exposure, glycemia and insulin levels decrease and insulin sensitivity increases, which can …