Noble gas and neuroprotection: From bench to bedside

H Yin, Z Chen, H Zhao, H Huang, W Liu - Frontiers in Pharmacology, 2022 - frontiersin.org
In recent years, inert gases such as helium, argon, and xenon have gained considerable
attention for their medical value. Noble gases present an intriguing scientific paradox …

Noble gases therapy in cardiocerebrovascular diseases: the novel stars?

J Zhang, W Liu, M Bi, J Xu, H Yang… - Frontiers in …, 2022 - frontiersin.org
Cardiocerebrovascular diseases (CCVDs) are the leading cause of death worldwide;
therefore, to deeply explore the pathogenesis of CCVDs and to find the cheap and efficient …

Treatment with inhaled Argon: a systematic review of pre-clinical and clinical studies with meta-analysis on neuroprotective effect

G Merigo, G Florio, F Madotto, A Magliocca, I Silvestri… - …, 2024 - thelancet.com
Summary Background Argon (Ar) has been proposed as a potential therapeutic agent in
multiple clinical conditions, specifically in organ protection. However, conflicting data on pre …

Argon mediates protection by interleukin‐8 suppression via a TLR2/TLR4/STAT3/NF‐κB pathway in a model of apoptosis in neuroblastoma cells in vitro and following ischemia …

F Ulbrich, T Lerach, J Biermann… - Journal of …, 2016 - Wiley Online Library
Argon has recently come into scientific focus as a neuroprotective agent. The underlying
neuroprotective mechanism remains unknown although toll‐like receptors were recently …

[HTML][HTML] Neuroprotection by the noble gases argon and xenon as treatments for acquired brain injury: a preclinical systematic review and meta-analysis

M Liang, F Ahmad, R Dickinson - British Journal of Anaesthesia, 2022 - Elsevier
Background The noble gases argon and xenon are potential novel neuroprotective
treatments for acquired brain injuries. Xenon has already undergone early-stage clinical …

Update of the organoprotective properties of xenon and argon: from bench to beside

R Anna, R Rolf, C Mark - Intensive care medicine experimental, 2020 - Springer
The growth of the elderly population has led to an increase in patients with myocardial
infarction and stroke (Wajngarten and Silva, Eur Cardiol 14: 111–115, 2019). Patients …

[HTML][HTML] Efficacy of acute administration of inhaled argon on traumatic brain injury in mice

F Moro, F Fossi, A Magliocca, R Pascente… - British Journal of …, 2021 - Elsevier
Background Whilst there has been progress in supportive treatment for traumatic brain injury
(TBI), specific neuroprotective interventions are lacking. Models of ischaemic heart and brain …

Ventilation with argon improves survival with good neurological recovery after prolonged untreated cardiac arrest in pigs

F Fumagalli, D Olivari, A Boccardo… - Journal of the …, 2020 - Am Heart Assoc
Background Ventilation with the noble gas argon (Ar) has shown neuroprotective and
cardioprotective properties in different in vitro and in vivo models. Hence, the …

Argon: systematic review on neuro-and organoprotective properties of an “inert” gas

A Höllig, A Schug, AV Fahlenkamp, R Rossaint… - International Journal of …, 2014 - mdpi.com
Argon belongs to the group of noble gases, which are regarded as chemically inert.
Astonishingly some of these gases exert biological properties and during the last decades …

Argon mediates anti-apoptotic signaling and neuroprotection via inhibition of toll-like receptor 2 and 4

F Ulbrich, K Kaufmann, M Roesslein, F Wellner… - PloS one, 2015 - journals.plos.org
Purpose Recently, the noble gas argon attracted significant attention due to its
neuroprotective properties. However, the underlying molecular mechanism is still poorly …