Despite centuries since the discovery and study of cancer, cancer is still a lethal and
intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much …

The view of cancer as a tumor cell-centric disease is now replaced by our understanding of
the interconnection and dependency of tumor stroma. Cancer-associated fibroblasts (CAFs) …

Fibroblasts display extensive transcriptional heterogeneity, yet functional annotation and
characterization of their heterocellular relationships remains incomplete. Using mass …

Prostate cancer is characterized by a high degree of heterogeneity, which poses a major
challenge to precision therapy and drug development. In this review, we discuss how …

Tumors strongly depend on their surrounding tumor microenvironment (TME) for growth and
progression, since stromal elements are required to generate the optimal conditions for …

Since the" seed and soil" hypothesis was proposed, the biological functions of the tumor
microenvironment (TME), especially its stromal components, have received increasing …

Cancer-associated fibroblasts (CAFs) in the tumor microenvironment are often linked to drug
resistance. Here, we found that coculture with CAFs or culture in CAF-conditioned medium …

Neoplastic epithelial cells coexist in carcinomas with various non-neoplastic stromal cells,
together creating the tumor microenvironment. There is a growing interest in the cross-talk …

Cancer-associated fibroblasts (CAFs) promote tumor malignancy, but the precise
transcriptional mechanisms regulating the acquisition of the CAF phenotype are not well …

The genomic, epigenetic and metabolic determinants of prostate cancer pathobiology have
been extensively studied in epithelial cancer cells. However, malignant cells constantly …