The role of reactive oxygen species in antibiotic-mediated killing of bacteria
H Van Acker, T Coenye - Trends in microbiology, 2017 - cell.com
Recently, it was proposed that there is a common mechanism behind the activity of
bactericidal antibiotics, involving the production of reactive oxygen species (ROS). However …
bactericidal antibiotics, involving the production of reactive oxygen species (ROS). However …
Combating antibiotic tolerance through activating bacterial metabolism
Y Liu, K Yang, H Zhang, Y Jia, Z Wang - Frontiers in Microbiology, 2020 - frontiersin.org
The emergence of antibiotic tolerance enables genetically susceptible bacteria to withstand
the killing by clinically relevant antibiotics. As is reported, an increasing body of evidence …
the killing by clinically relevant antibiotics. As is reported, an increasing body of evidence …
Potentiating antibiotics in drug-resistant clinical isolates via stimuli-activated superoxide generation
The rise of multidrug-resistant (MDR) bacteria is a growing concern to global health and is
exacerbated by the lack of new antibiotics. To treat already pervasive MDR infections, new …
exacerbated by the lack of new antibiotics. To treat already pervasive MDR infections, new …
Antibiotic efficacy—context matters
Highlights•Antibiotic lethality involves processes downstream of primary target
inhibition.•Respiration and altered metabolism actively participate in antibiotic lethality.• …
inhibition.•Respiration and altered metabolism actively participate in antibiotic lethality.• …
Bioenergetic Inhibitors: Antibiotic Efficacy and Mechanisms of Action in Mycobacterium tuberculosis
EJ Hasenoehrl, TJ Wiggins, M Berney - Frontiers in cellular and …, 2021 - frontiersin.org
Development of novel anti-tuberculosis combination regimens that increase efficacy and
reduce treatment timelines will improve patient compliance, limit side-effects, reduce costs …
reduce treatment timelines will improve patient compliance, limit side-effects, reduce costs …
Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction
DNA synthesis by DNA polymerases (dPols) is central to duplication and maintenance of the
genome in all living organisms. dPols catalyze the formation of a phosphodiester bond …
genome in all living organisms. dPols catalyze the formation of a phosphodiester bond …
Plasmid-mediated quinolone resistance in Enterobacteriaceae: a systematic review with a focus on Mediterranean countries
Quinolones are a family of synthetic broad-spectrum antimicrobial drugs. These molecules
have been widely prescribed to treat various infectious diseases and have been classified …
have been widely prescribed to treat various infectious diseases and have been classified …
Proteomic investigation into the action mechanism of berberine against Streptococcus pyogenes
GF Du, YJ Le, X Sun, XY Yang, QY He - Journal of proteomics, 2020 - Elsevier
Berberine is an isoquinoline alkaloid found in many plants. Although berberine is known to
possess the antibacterial activity against Streptococcus pyogenes, the mechanism …
possess the antibacterial activity against Streptococcus pyogenes, the mechanism …
[HTML][HTML] Occurrence and removal prediction of pharmaceuticals positively correlated with antibiotic resistance genes in wastewater treatment processes
B Liu, Y Xu, F Liu, B Li, X Li, R Zha, S Wang… - … Technology & Innovation, 2023 - Elsevier
Wastewater treatment plants (WWTPs) are important source of pharmaceuticals in the
environment, identifying their relationship with antibiotic resistance genes (ARGs) and …
environment, identifying their relationship with antibiotic resistance genes (ARGs) and …
N-acetylcysteine blocks SOS induction and mutagenesis produced by fluoroquinolones in Escherichia coli
AI Rodríguez-Rosado, EY Valencia… - Journal of …, 2019 - academic.oup.com
Background Fluoroquinolones such as ciprofloxacin induce the mutagenic SOS response
and increase the levels of intracellular reactive oxygen species (ROS). Both the SOS …
and increase the levels of intracellular reactive oxygen species (ROS). Both the SOS …