Recently, it was proposed that there is a common mechanism behind the activity of
bactericidal antibiotics, involving the production of reactive oxygen species (ROS). However …

The emergence of antibiotic tolerance enables genetically susceptible bacteria to withstand
the killing by clinically relevant antibiotics. As is reported, an increasing body of evidence …

The rise of multidrug-resistant (MDR) bacteria is a growing concern to global health and is
exacerbated by the lack of new antibiotics. To treat already pervasive MDR infections, new …

Highlights•Antibiotic lethality involves processes downstream of primary target
inhibition.•Respiration and altered metabolism actively participate in antibiotic lethality.• …

Development of novel anti-tuberculosis combination regimens that increase efficacy and
reduce treatment timelines will improve patient compliance, limit side-effects, reduce costs …

DNA synthesis by DNA polymerases (dPols) is central to duplication and maintenance of the
genome in all living organisms. dPols catalyze the formation of a phosphodiester bond …

Quinolones are a family of synthetic broad-spectrum antimicrobial drugs. These molecules
have been widely prescribed to treat various infectious diseases and have been classified …

Berberine is an isoquinoline alkaloid found in many plants. Although berberine is known to
possess the antibacterial activity against Streptococcus pyogenes, the mechanism …

Wastewater treatment plants (WWTPs) are important source of pharmaceuticals in the
environment, identifying their relationship with antibiotic resistance genes (ARGs) and …

Background Fluoroquinolones such as ciprofloxacin induce the mutagenic SOS response
and increase the levels of intracellular reactive oxygen species (ROS). Both the SOS …