Cells undergo a major epigenome reconfiguration when reprogrammed to human induced
pluripotent stem cells (hiPS cells). However, the epigenomes of hiPS cells and human …

Abstract Metabolic Syndrome (MetS) is a highly heritable disease and a major public health
burden worldwide. MetS diagnosis criteria is met by the simultaneous presence of any three …

Library preparation protocols for most sequencing technologies involve PCR amplification of
the template DNA, which open the possibility that a given template DNA molecule is …

In-silico classification of the pathogenic status of somatic variants is shown to be promising
in promoting the clinical utilization of genetic tests. Majority of the available classification …

DNA methylation is an important epigenetic change affecting gene expression in plants in
both normal and stress conditions. The organelles, mitochondria and chloroplast play a …

Exposure to childhood maltreatment (CM) has consistently been linked to an increased risk
for developing psychiatric disorders later on in life. Epigenetic mechanisms such as DNA …

Rett Syndrome (RTT) is a severe dominant X-linked neurological disorder affecting 1:
10,000 females. In-95% of the cases, RTT is caused by deleterious mutations in the Methyl …