Umbilical cord blood is an alternative hematopoietic stem cell source for patients with
hematologic diseases who can be cured by allogeneic hematopoietic cell transplantation …

Adoptive cell therapy has emerged as a powerful treatment for advanced cancers resistant
to conventional agents. Most notable are the remarkable responses seen in patients …

Checkpoint blockade immunotherapy targeting the PD-1/PD-L1 inhibitory axis has produced
remarkable results in the treatment of several types of cancer. Whereas cytotoxic T cells are …

Background Of the cancers treated with allogeneic hematopoietic stem-cell transplantation
(HSCT), acute myeloid leukemia (AML) is most sensitive to natural killer (NK)–cell reactivity …

Thirteen patients with acute myeloid leukemia, 5 with active disease, 2 in molecular relapse,
and 6 in morphologic complete remission (CR; median age, 62 years; range, 53-73 years) …

Effectiveness of double umbilical cord blood (dUCB) grafts relative to conventional marrow
and mobilized peripheral blood from related and unrelated donors has yet to be established …

Natural killer (NK) cells can enhance engraftment and mediate graft-versus-leukemia
following allogeneic hematopoietic stem cell transplantation (HSCT), but the potency of graft …

The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the
engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia …

Chimeric antigen receptor (CAR)-modified natural killer (NK) cells represent a promising
immunotherapeutic modality for cancer treatment. However, their potential utilities have not …

Natural killer (NK) cells are lymphocytes of the innate immune system able to kill different
targets such as cancer cells and virally infected cells without prior activation making then …