Sildenafil is a new approach to treat fetal growth restriction (FGR) and preeclampsia. We
performed a systematic meta-analysis to evaluate effects of sildenafil. Our search identified …

Preeclampsia is a hypertensive disorder of pregnancy and the clinical manifestation of
severe endothelial dysfunction associated with maternal and foetal morbidity and mortality …

BKCa channels (large-conductance Ca2+-activated K+ channels) play a critical role in
regulating vascular tone and blood pressure. These channels are present in the smooth …

Preeclampsia (PE) is a common pregnancy-related hypertensive disorder and is a leading
cause of maternal and perinatal morbidity and mortality. The incidence of PE and its …

Sildenafil has shown nitric oxide (NO)-independent pleiotropic effects, however the
mechanisms involved are unclear. We investigated the protective effects of sildenafil against …

Abstract Background Myoinositol (M) and D-chiro-inositol (D) are insulin sensitizer
compounds, while fucoxanthin (F) and hydroxytyrosol (H) are antioxidant substances. We …

The maternal innate immune system plays a central role in preeclampsia (PE). Toll-like
receptors (TLRs) are innate immune system receptors that recognize characteristics of …

Hypertensive disorders of pregnancy complicate up to 10% of pregnancies worldwide, and
they can be classified into (1) gestational hypertension,(2) preeclampsia,(3) chronic …

Preeclampsia (PE) is a common pregnancy-related hypertensive disorder and is a leading
cause of maternal and perinatal morbidity and mortality. The incidence of PE and its …

Pregnancy induced hypertension (PIH) is the most common complication during pregnancy
and it affects up to 12% of pregnancies. It is the leading cause of maternal and fetal …