The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the
orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of …

Traditional organic antimicrobials mainly act on specific biochemical processes such as
replication, transcription and translation. However, the emergence and wide spread of …

The development of new and effective antibacterial drugs to treat multi-drug resistant (MDR)
bacteria, especially Gram-negative (G− ve) pathogens, is acknowledged as one of the …

History of mankind is regarded as struggle against infectious diseases. Rather than
observing the withering away of bacterial diseases, antibiotic resistance has emerged as a …

Auranofin (AUR) is an orally available lipophilic gold-based anti-inflammatory compound
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …

Antimicrobial resistance (AMR) is one of the greatest global health challenges of modern
times and its prevalence is rising worldwide. AMR within bacteria reduces the efficacy of …

With the widespread rise of antimicrobial resistance, most traditional sources for new drug
compounds have been explored intensively for new classes of antibiotics. Meanwhile, metal …

Multidrug-resistant (MDR) pathogens pose a well-recognized global health threat that
demands effective solutions; the situation is deemed a global priority by the World Health …

Methicillin-resistant Staphylococcus aureus (MRSA) infections present a serious challenge
because of the emergence of resistance to numerous conventional antibiotics. Due to their …

In order to mitigate antibiotic resistance, a new strategy to increase antibiotic potency and
reverse drug resistance is needed. Herein, the translocation mechanism of an antimicrobial …