David vs. Goliath: the structure, function, and clinical prospects of antibody fragments

A Bates, CA Power - Antibodies, 2019 - mdpi.com
Since the licensing of the first monoclonal antibody therapy in 1986, monoclonal antibodies
have become the largest class of biopharmaceuticals with over 80 antibodies currently …

Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelope

WW Navarre, O Schneewind - Microbiology and molecular biology …, 1999 - Am Soc Microbiol
The cell wall envelope of gram-positive bacteria is a macromolecular, exoskeletal organelle
that is assembled and turned over at designated sites. The cell wall also functions as a …

The wound microbiota: microbial mechanisms of impaired wound healing and infection

A Uberoi, A McCready-Vangi, EA Grice - Nature Reviews Microbiology, 2024 - nature.com
The skin barrier protects the human body from invasion by exogenous and pathogenic
microorganisms. A breach in this barrier exposes the underlying tissue to microbial …

Gram-positive anaerobic cocci–commensals and opportunistic pathogens

EC Murphy, IM Frick - FEMS microbiology reviews, 2013 - academic.oup.com
Among the Gram-positive anaerobic bacteria associated with clinical infections, the Gram-
positive anaerobic cocci (GPAC) are the most prominent and account for approximately 25 …

Protein A chromatography: Challenges and progress in the purification of monoclonal antibodies

AM Ramos‐de‐la‐Peña… - Journal of separation …, 2019 - Wiley Online Library
Antibodies for therapeutic use are being continuously approved and their demand has been
steadily growing. As known, the golden standard for monoclonal antibody (mAb) purification …

Superantigen recognition and interactions: functions, mechanisms and applications

AM Deacy, SKE Gan, JP Derrick - Frontiers in Immunology, 2021 - frontiersin.org
Superantigens are unconventional antigens which recognise immune receptors outside
their usual recognition sites eg complementary determining regions (CDRs), to elicit a …

[图书][B] Handbook of affinity chromatography

T Kline - 1993 - taylorfrancis.com
Outlining the fundamental principles by which all interactions occur, this reference focuses
on harnessing the biochemistry of bioorganic compounds in order to separate them …

Protein L from Peptostreptococcus magnus binds to the kappa light chain variable domain.

BH Nilson, A Solomon, L Björck, B Akerström - Journal of Biological …, 1992 - ASBMB
Protein L is an immunoglobulin light chain-binding protein expressed by some strains of the
anaerobic bacterial species Peptostreptococcus magnus. The major variable region …

Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation

AR Cruz, MA Boer, J Strasser… - Proceedings of the …, 2021 - National Acad Sciences
Immunoglobulin (Ig) G molecules are essential players in the human immune response
against bacterial infections. An important effector of IgG-dependent immunity is the induction …

Production of correctly folded Fab antibody fragment in the cytoplasm of Escherichia coli trxB gor mutants via the coexpression of molecular chaperones

R Levy, R Weiss, G Chen, BL Iverson… - Protein expression and …, 2001 - Elsevier
Disulfide bonds are normally formed after a polypeptide has been exported from the
reducing environment of the cytoplasm into a more oxidizing compartment, such as the …