Drosophila Heart as a Model for Cardiac Development and Diseases
A Souidi, K Jagla - Cells, 2021 - mdpi.com
The Drosophila heart, also referred to as the dorsal vessel, pumps the insect blood, the
hemolymph. The bilateral heart primordia develop from the most dorsally located …
hemolymph. The bilateral heart primordia develop from the most dorsally located …
Mechanical analysis of Drosophila indirect flight and jump muscles
DM Swank - Methods, 2012 - Elsevier
The genetic advantages of Drosophila make it a very appealing choice for investigating
muscle development, muscle physiology and muscle protein structure and function. To take …
muscle development, muscle physiology and muscle protein structure and function. To take …
Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in …
AS Trujillo, KH Hsu, J Puthawala… - Molecular biology of …, 2021 - Am Soc Cell Biol
Dilated cardiomyopathy (DCM), a life-threatening disease characterized by pathological
heart enlargement, can be caused by myosin mutations that reduce contractile function. To …
heart enlargement, can be caused by myosin mutations that reduce contractile function. To …
The relay/converter interface influences hydrolysis of ATP by skeletal muscle myosin II
The interface between relay and converter domain of muscle myosin is critical for optimal
myosin performance. Using Drosophila melanogaster indirect flight muscle S1, we …
myosin performance. Using Drosophila melanogaster indirect flight muscle S1, we …
Inter-Species Rescue of Mutant Phenotype—The Standard for Genetic Analysis of Human Genetic Disorders in Drosophila melanogaster Model
AA Ecovoiu, AC Ratiu, MM Micheu… - International Journal of …, 2022 - mdpi.com
Drosophila melanogaster (the fruit fly) is arguably a superstar of genetics, an astonishing
versatile experimental model which fueled no less than six Nobel prizes in medicine …
versatile experimental model which fueled no less than six Nobel prizes in medicine …
A restrictive cardiomyopathy mutation in an invariant proline at the myosin head/rod junction enhances head flexibility and function, yielding muscle defects in …
M Achal, AS Trujillo, GC Melkani, GP Farman… - Journal of molecular …, 2016 - Elsevier
An “invariant proline” separates the myosin S1 head from its S2 tail and is proposed to be
critical for orienting S1 during its interaction with actin, a process that leads to muscle …
critical for orienting S1 during its interaction with actin, a process that leads to muscle …
Mapping interactions between myosin relay and converter domains that power muscle function
WA Kronert, GC Melkani, A Melkani… - Journal of Biological …, 2014 - ASBMB
Intramolecular communication within myosin is essential for its function as motor, but the
specific amino acid residue interactions required are unexplored within muscle cells. Using …
specific amino acid residue interactions required are unexplored within muscle cells. Using …
Expression of the inclusion body myopathy 3 mutation in Drosophila depresses myosin function and stability and recapitulates muscle inclusions and weakness
Y Wang, GC Melkani, JA Suggs, A Melkani… - Molecular biology of …, 2012 - Am Soc Cell Biol
Hereditary myosin myopathies are characterized by variable clinical features. Inclusion body
myopathy 3 (IBM-3) is an autosomal dominant disease associated with a missense mutation …
myopathy 3 (IBM-3) is an autosomal dominant disease associated with a missense mutation …
Alternative relay and converter domains tune native muscle myosin isoform function in Drosophila
WA Kronert, GC Melkani, A Melkani… - Journal of molecular …, 2012 - Elsevier
Myosin isoforms help define muscle-specific contractile and structural properties. Alternative
splicing of myosin heavy chain gene transcripts in Drosophila melanogaster yields muscle …
splicing of myosin heavy chain gene transcripts in Drosophila melanogaster yields muscle …
Transgenic expression and purification of myosin isoforms using the Drosophila melanogaster indirect flight muscle system
Biophysical and structural studies on muscle myosin rely upon milligram quantities of
extremely pure material. However, many biologically interesting myosin isoforms are …
extremely pure material. However, many biologically interesting myosin isoforms are …