DNA double-strand break repair-pathway choice in somatic mammalian cells
The major pathways of DNA double-strand break (DSB) repair are crucial for maintaining
genomic stability. However, if deployed in an inappropriate cellular context, these same …
genomic stability. However, if deployed in an inappropriate cellular context, these same …
Breaking the chains: deubiquitylating enzyme specificity begets function
The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases)
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …
[HTML][HTML] Histone ubiquitination: an integrative signaling platform in genome stability
F Mattiroli, L Penengo - Trends in Genetics, 2021 - cell.com
Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …
Comprehensive mapping of histone modifications at DNA double-strand breaks deciphers repair pathway chromatin signatures
Double-strand breaks (DSBs) are extremely detrimental DNA lesions that can lead to cancer-
driving mutations and translocations. Non-homologous end joining (NHEJ) and homologous …
driving mutations and translocations. Non-homologous end joining (NHEJ) and homologous …
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
Y Shiloh, Y Ziv - Nature reviews Molecular cell biology, 2013 - nature.com
The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an
apical activator of the DNA damage response in the face of DNA double-strand breaks …
apical activator of the DNA damage response in the face of DNA double-strand breaks …
Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers
P Schwertman, S Bekker-Jensen… - Nature reviews Molecular …, 2016 - nature.com
DNA double-strand breaks (DSBs) are highly cytotoxic DNA lesions. The swift recognition
and faithful repair of such damage is crucial for the maintenance of genomic stability, as well …
and faithful repair of such damage is crucial for the maintenance of genomic stability, as well …
Regulation of nucleosome dynamics by histone modifications
GE Zentner, S Henikoff - Nature structural & molecular biology, 2013 - nature.com
Chromatin is a dynamic structure that must respond to myriad stimuli to regulate access to
DNA, and chemical modification of histones is a major means by which the cell modulates …
DNA, and chemical modification of histones is a major means by which the cell modulates …
The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis
A Shilatifard - Annual review of biochemistry, 2012 - annualreviews.org
The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4)
methylase identified over 10 years ago. Since then, it has been demonstrated that …
methylase identified over 10 years ago. Since then, it has been demonstrated that …
RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling
F Mattiroli, JHA Vissers, WJ van Dijk, P Ikpa, E Citterio… - Cell, 2012 - cell.com
Ubiquitin-dependent signaling during the DNA damage response (DDR) to double-strand
breaks (DSBs) is initiated by two E3 ligases, RNF8 and RNF168, targeting histone H2A and …
breaks (DSBs) is initiated by two E3 ligases, RNF8 and RNF168, targeting histone H2A and …
Regulation of DNA damage responses by ubiquitin and SUMO
SP Jackson, D Durocher - Molecular cell, 2013 - cell.com
Ubiquitylation and sumoylation, the covalent attachment of the polypeptides ubiquitin and
SUMO, respectively, to target proteins, are pervasive mechanisms for controlling cellular …
SUMO, respectively, to target proteins, are pervasive mechanisms for controlling cellular …