Optimising mechanical ventilation through model-based methods and automation

SE Morton, JL Knopp, JG Chase, P Docherty… - Annual Reviews in …, 2019 - Elsevier
Mechanical ventilation (MV) is a core life-support therapy for patients suffering from
respiratory failure or acute respiratory distress syndrome (ARDS). Respiratory failure is a …

Model-based estimation of negative inspiratory driving pressure in patients receiving invasive NAVA mechanical ventilation

JL Knopp, JG Chase, KT Kim, GM Shaw - Computer Methods and Programs …, 2021 - Elsevier
Background Optimisation of mechanical ventilation (MV) and weaning requires insight into
underlying patient breathing effort. Current identifiable models effectively describe lung …

Prediction and estimation of pulmonary response and elastance evolution for volume-controlled and pressure-controlled ventilation

Q Sun, JG Chase, C Zhou, MH Tawhai… - … Signal Processing and …, 2022 - Elsevier
Mechanical ventilation (MV) is a core treatment for patients suffering from respiratory
disease and failure. However, MV settings are not standardized due to significant inter-and …

Assessing mechanical ventilation asynchrony through iterative airway pressure reconstruction

YS Chiew, CP Tan, JG Chase, YW Chiew… - Computer methods and …, 2018 - Elsevier
Background and objective Respiratory mechanics estimation can be used to guide
mechanical ventilation (MV) but is severely compromised when asynchronous breathing …

A machine learning approach to assess magnitude of asynchrony breathing

NL Loo, YS Chiew, CP Tan, MB Mat-Nor… - … signal processing and …, 2021 - Elsevier
Background Conventional patient-ventilator interaction (PVI) assessment involves manual
asynchronous index (AI) computation and incapable to provide in-depth information of the …

Quantification of respiratory effort magnitude in spontaneous breathing patients using Convolutional Autoencoders

CYS Ang, YS Chiew, LH Vu, ME Cove - Computer Methods and Programs …, 2022 - Elsevier
Background Spontaneous breathing (SB) effort during mechanical ventilation (MV) is an
important metric of respiratory drive. However, SB effort varies due to a variety of factors …

Reconstructing asynchrony for mechanical ventilation using a hysteresis loop virtual patient model

C Zhou, JG Chase, Q Sun, J Knopp, MH Tawhai… - BioMedical Engineering …, 2022 - Springer
Background Patient-specific lung mechanics during mechanical ventilation (MV) can be
identified from measured waveforms of fully ventilated, sedated patients. However …

Quantifying patient spontaneous breathing effort using model-based methods

KT Kim, J Knopp, JG Chase - Biomedical Signal Processing and Control, 2021 - Elsevier
Background Spontaneous breathing (SB) effort is common in invasively ventilated patients,
as they recover or at low sedation levels. SB effort makes estimation of patient-specific lung …

Mixed‐integer quadratic programming approach for noninvasive estimation of respiratory effort profile during pressure support ventilation

MH Victor Jr, MROA Maximo… - International Journal …, 2023 - Wiley Online Library
Abstract Information about respiratory mechanics such as resistance, elastance, and
muscular pressure is important to mitigate ventilator‐induced lung injury. Particularly during …

Patient asynchrony modelling during controlled mechanical ventilation therapy

GR Arunachalam, YS Chiew, CP Tan, AM Ralib… - Computer Methods and …, 2020 - Elsevier
Background and objective Mechanical ventilation therapy of respiratory failure patients can
be guided by monitoring patient-specific respiratory mechanics. However, the patient's …