Paranodal axoglial junctions, an essential component in axonal homeostasis

T Ishibashi, H Baba - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
In vertebrates, a high density of voltage-gated Na+ channel at nodes of Ranvier and of
voltage-gated K+ channel at juxtaparanodes is necessary for rapid propagation of action …

Radial contractility of actomyosin rings facilitates axonal trafficking and structural stability

T Wang, W Li, S Martin, A Papadopulos… - Journal of Cell …, 2020 - rupress.org
Most mammalian neurons have a narrow axon, which constrains the passage of large
cargoes such as autophagosomes that can be larger than the axon diameter. Radial axonal …

Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function

D Lang-Ouellette, KM Gruver, A Smith-Dijak… - Nature …, 2021 - nature.com
Axonal plasticity allows neurons to control their output, which critically determines the flow of
information in the brain. Axon diameter can be regulated by activity, yet how morphological …

Understanding the pathogenic mechanisms and therapeutic effects in neurocysticercosis

G Castillo, L Fustamante… - Brain …, 2024 - Wiley Online Library
Despite being a leading cause of acquired seizures in endemic regions, the pathological
mechanisms of neurocysticercosis are still poorly understood. This study aims to investigate …

Preparation recombination human‐like collagen/fibroin scaffold and promoting the cell compatibility with osteoblasts

K Hu, M Hu, YH Xiao, Y Cui, J Yan… - … Research Part A, 2021 - Wiley Online Library
On this basis, a novel recombinant human‐like collagen (RHLC)/silk fibroin scaffold material
with high porosity and controllable aperture was prepared. The compatibility of osteoblasts …

TBK1 Knockdown Alleviates Axonal Transport Deficits in Retinal Ganglion Cells Via mTORC1 Activation in a Retinal Damage Mouse Model

M Ye, Y Hu, B Zhao, Q Mou, Y Ni, J Luo… - … & Visual Science, 2023 - iovs.arvojournals.org
Purpose: Glaucoma is the leading cause of irreversible blindness worldwide and is
characterized by progressive retinal ganglion cell (RGC) death and optic nerve …

Reaction time impairments in decision-making networks as a diagnostic marker for traumatic brain injuries and neurological diseases

PD Maia, JN Kutz - Journal of computational neuroscience, 2017 - Springer
The presence of diffuse Focal Axonal Swellings (FAS) is a hallmark cellular feature in many
neurological diseases and traumatic brain injury. Among other things, the FAS have a …

Axons-on-a-chip for mimicking non-disruptive diffuse axonal injury underlying traumatic brain injury

X Pan, J Li, W Li, H Wang, N Durisic, Z Li, Y Feng… - Lab on a Chip, 2022 - pubs.rsc.org
Diffuse axonal injury (DAI) is the most severe pathological feature of traumatic brain injury
(TBI). However, how primary axonal injury is induced by transient mechanical impacts …

Functionality and Robustness of Injured Connectomic Dynamics in C. elegans: Linking Behavioral Deficits to Neural Circuit Damage

JM Kunert, PD Maia, JN Kutz - PLoS computational biology, 2017 - journals.plos.org
Using a model for the dynamics of the full somatic nervous system of the nematode C.
elegans, we address how biological network architectures and their functionality are …

Modeling cognitive deficits following neurodegenerative diseases and traumatic brain injuries with deep convolutional neural networks

B Lusch, J Weholt, PD Maia, JN Kutz - Brain and cognition, 2018 - Elsevier
The accurate diagnosis and assessment of neurodegenerative disease and traumatic brain
injuries (TBI) remain open challenges. Both cause cognitive and functional deficits due to …