Skeletal muscle is the tissue directly involved in insulin-stimulated glucose uptake. Glucose
is the primary energy substrate for contracting muscles, and proper metabolism of glucose is …

A long-term high-energy diet affects human health and leads to obesity and metabolic
syndrome in addition to cardiac steatosis and hypertrophy. Ectopic fat accumulation in the …

Schwann cells produce a considerable amount of lipids and proteins to form myelin in the
PNS. For this reason, the quality control of myelin proteins is crucial to ensure proper myelin …

Calcineurin is a calcium‐dependent phosphatase that is involved in many cellular
processes including hypertrophy. Inhibition or genetic loss of calcineurin blocks pathological …

Tacrolimus is a widely used immunosuppressive drug, which requires a binding partner,
FKBP12 to inhibit its canonical target calcineurin. FKBP12, however, has its own important …