Regulatory crosstalk between the oxidative stress-related transcription factor Nfe2l2/Nrf2 and mitochondria

I Ryoo, MK Kwak - Toxicology and applied pharmacology, 2018 - Elsevier
Mitochondria play essential roles in cellular bioenergetics, biosynthesis, and apoptosis.
During the process of respiration and oxidative phosphorylation, mitochondria utilize oxygen …

Natural polyphenols: a potential prevention and treatment strategy for metabolic syndrome

S Wang, Q Du, X Meng, Y Zhang - Food & Function, 2022 - pubs.rsc.org
Metabolic syndrome (MS) is the term for a combination of hypertension, dyslipidemia, insulin
resistance, and central obesity as factors leading to cardiovascular and metabolic disease …

[HTML][HTML] Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway

XJ Zhao, HW Yu, YZ Yang, WY Wu, TY Chen, KK Jia… - Redox Biology, 2018 - Elsevier
Oxidative stress is a critical factor in nonalcoholic fatty liver disease pathogenesis.
MicroRNA-200a (miR-200a) is reported to target Kelch-like ECH-associated protein 1 …

Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation

X Feng, W Yu, X Li, F Zhou, W Zhang, Q Shen… - Biochemical …, 2017 - Elsevier
Lipid metabolic disorders and oxidative stress in the liver are key steps in the progression of
nonalcoholic fatty liver disease (NAFLD), which is a major risk factor for the development of …

Natural polyphenols in metabolic syndrome: protective mechanisms and clinical applications

S Zhang, M Xu, W Zhang, C Liu, S Chen - International journal of …, 2021 - mdpi.com
Metabolic syndrome (MetS) is a chronic disease, including abdominal obesity, dyslipidemia,
hyperglycemia, and hypertension. It should be noted that the occurrence of MetS is closely …

Pomegranate juice as a functional food: A comprehensive review of its polyphenols, therapeutic merits, and recent patents

H Fahmy, N Hegazi, S El-Shamy, MA Farag - Food & function, 2020 - pubs.rsc.org
Pomegranate (Punica granatum) is an ancient perennial plant species of the Punicaceae
family and is regarded as the 'miracle fruit'for its seeds being consumed as food, juice and …

Punicalagin protects against diabetic liver injury by upregulating mitophagy and antioxidant enzyme activities

Y Zhang, X Tan, Y Cao, X An, J Chen, L Yang - Nutrients, 2022 - mdpi.com
Diabetic liver injury has received increasing attention as a serious complication of type 2
diabetes. Punicalagin (PU), a major component of pomegranate polyphenols, has various …

Ongoing and potential novel trends of pomegranate fruit peel; a comprehensive review of its health benefits and future perspectives as nutraceutical

HA Fahmy, MA Farag - Journal of Food Biochemistry, 2022 - Wiley Online Library
Pomegranate is an ancient shrub, globally distributed nowadays. It has been used in the
middle east as a medicinal food and traditional medicine for thousands of years …

Beneficial effects of pomegranate on lipid metabolism in metabolic disorders

C Hou, W Zhang, J Li, L Du, O Lv… - Molecular nutrition & …, 2019 - Wiley Online Library
Abstract Pomegranate (Punica granatum Linn) is used in the prevention and treatment of
metabolic syndrome in recent decades. Imbalances in lipid metabolism are profound …

Activation of Atg7-dependent autophagy by a novel inhibitor of the Keap1–Nrf2 protein–protein interaction from Penthorum chinense Pursh. attenuates 6 …

Y Sun, L He, W Wang, Z Xie, X Zhang, P Wang… - Food & Function, 2022 - pubs.rsc.org
The death of dopaminergic neurons is a dominant factor during the occurrence and
development of Parkinson's disease (PD). Previous studies demonstrated that ferroptosis is …