GTRD: an integrated view of transcription regulation
S Kolmykov, I Yevshin, M Kulyashov… - Nucleic acids …, 2021 - academic.oup.com
Abstract The Gene Transcription Regulation Database (GTRD; http://gtrd. biouml. org/)
contains uniformly annotated and processed NGS data related to gene transcription …
contains uniformly annotated and processed NGS data related to gene transcription …
[HTML][HTML] A guide to conquer the biological network era using graph theory
Networks are one of the most common ways to represent biological systems as complex sets
of binary interactions or relations between different bioentities. In this article, we discuss the …
of binary interactions or relations between different bioentities. In this article, we discuss the …
JASPAR 2020: update of the open-access database of transcription factor binding profiles
Abstract JASPAR (http://jaspar. genereg. net) is an open-access database of curated, non-
redundant transcription factor (TF)-binding profiles stored as position frequency matrices …
redundant transcription factor (TF)-binding profiles stored as position frequency matrices …
A gene–environment-induced epigenetic program initiates tumorigenesis
Tissue damage increases the risk of cancer through poorly understood mechanisms. In
mouse models of pancreatic cancer, pancreatitis associated with tissue injury collaborates …
mouse models of pancreatic cancer, pancreatitis associated with tissue injury collaborates …
[HTML][HTML] Aging is associated with a systemic length-associated transcriptome imbalance
Aging is among the most important risk factors for morbidity and mortality. To contribute
toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data …
toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data …
The TP53 apoptotic network is a primary mediator of resistance to BCL2 inhibition in AML cells
To study mechanisms underlying resistance to the BCL2 inhibitor venetoclax in acute
myeloid leukemia (AML), we used a genome-wide CRISPR/Cas9 screen to identify gene …
myeloid leukemia (AML), we used a genome-wide CRISPR/Cas9 screen to identify gene …
[HTML][HTML] A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury
C Yang, H Xu, D Yang, Y Xie, M Xiong, Y Fan… - Nature …, 2023 - nature.com
Acute kidney injury (AKI) exhibits high morbidity and mortality. Kidney injury molecule-1
(KIM1) is dramatically upregulated in renal tubules upon injury, and acts as a biomarker for …
(KIM1) is dramatically upregulated in renal tubules upon injury, and acts as a biomarker for …
[HTML][HTML] Inflammatory cytokine–regulated tRNA-derived fragment tRF-21 suppresses pancreatic ductal adenocarcinoma progression
L Pan, X Huang, ZX Liu, Y Ye, R Li… - The Journal of …, 2021 - Am Soc Clin Investig
The tumorigenic mechanism for pancreatic ductal adenocarcinoma (PDAC) is not clear,
although chronic inflammation is implicated. Here, we identified an inflammatory cytokine …
although chronic inflammation is implicated. Here, we identified an inflammatory cytokine …
[HTML][HTML] Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration in mice
Y Cheng, Y Yin, A Zhang, AM Bernstein… - Nature …, 2022 - nature.com
The inability of neurons to regenerate long axons within the CNS is a major impediment to
improving outcome after spinal cord injury, stroke, and other CNS insults. Recent advances …
improving outcome after spinal cord injury, stroke, and other CNS insults. Recent advances …
[HTML][HTML] Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells
Although inhibition of T cell coinhibitory receptors has revolutionized cancer therapy, the
mechanisms governing their expression on human T cells have not been elucidated. In the …
mechanisms governing their expression on human T cells have not been elucidated. In the …