The PEA3 subfamily is a subgroup of the E26 transformation-specific (ETS) family. Its
members, ETV1, ETV4, and ETV5, have been found to be overexpressed in multiple …

The rate and rhythm of heart muscle contractions are coordinated by the cardiac conduction
system (CCS), a generic term for a collection of different specialized muscular tissues within …

Abstract Plakophilin-2 (PKP2) is a component of the desmosome and known for its role in
cell–cell adhesion. Mutations in human PKP2 associate with a life-threatening …

Rationale: The cardiac conduction system (CCS) consists of distinct components including
the sinoatrial node, atrioventricular node, His bundle, bundle branches, and Purkinje fibers …

Genome-wide association studies (GWAS) have made clear that single-nucleotide variants
(SNVs) that occur at multiple locations acrossthegenomecanbeassociatedwithasp…, also …

Accidental injury to the cardiac conduction system (CCS), a network of specialized cells
embedded within the heart and indistinguishable from the surrounding heart muscle tissue …

Background Metastasis is a major determinant of death in patients with hepatocellular
carcinoma (HCC). Dissecting key molecular mediators that promote this malignant feature …

Background: Brugada syndrome (BrS) is an inherited arrhythmia syndrome caused by loss-
of-function variants in the cardiac sodium channel gene SCN5A (sodium voltage-gated …

Background: Elevated intracardiac pressure attributable to heart failure induces electrical
and structural remodeling in the left atrium (LA) that begets atrial myopathy and arrhythmias …

The generation and propagation of the cardiac impulse is the central function of the cardiac
conduction system (CCS). Impulse initiation occurs in nodal tissues that have high levels of …