The Abelson (ABL) family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces
diverse extracellular signals to protein networks that control proliferation, survival, migration …

Sequential activation of kinases within the mitogen-activated protein (MAP) kinase (MAPK)
cascades is a common, and evolutionary-conserved mechanism of signal transduction. Four …

Mitogen-activated protein (MAP) kinases are a family of serine/threonine kinases that play a
central role in transducing extracellular cues into a variety of intracellular responses ranging …

c‐Abl is a non‐receptor tyrosine kinase which is localized both in the nucleus and
cytoplasm, and is involved in the regulation of cell growth, survival and morphogenesis …

Mitochondria are the major source of reactive oxygen species (ROS), whose aberrant
production by dysfunctional mitochondria leads to oxidative stress, thus contributing to aging …

Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved
catabolic process necessary for normal recycling of cellular constituents and for appropriate …

The Abelson (ABL) tyrosine kinases have been identified as drivers of leukemia in mice and
humans. Emerging data demonstrate a role for the ABL family kinases, ABL1 and ABL2, in …

The RET kinase has emerged as a promising target for the therapy of medullary thyroid
cancers (MTC) and of a subset of papillary thyroid cancers. NVP-AST487, a N, N′-diphenyl …

Multicellular organisms achieve intercellular communication by means of signalling
molecules whose effect on the target cell is mediated by signal transduction pathways. Such …

Classical hairy cell leukemia (HCL-c) is a rare lymphoid neoplasm. BRAF V600E mutation,
detected in more than 80% of the cases, is described as a driver mutation, but additional …