Primary aging is the progressive and inevitable process of bodily deterioration during
adulthood. In skeletal muscle, primary aging causes defective mitochondrial energetics and …

Sarcopenia is a progressive and widespread skeletal muscle disease that is related to an
increased possibility of adverse consequences such as falls, fractures, physical disabilities …

The relationship between the age-associated decline in mitochondrial function and its effect
on skeletal muscle physiology and function remain unclear. In the current study, we …

Abstract Background The Study of Muscle, Mobility and Aging (SOMMA) aims to understand
the biological basis of many facets of human aging, with a focus on mobility decline, by …

Superoxide, O2•−, is formed in all living organisms that come in contact with air, and,
depending upon its biological context, it may act as a signaling agent, a toxic species, or a …

Reactive oxidative species (ROS) toxicity remains an undisputed cause and link between
Alzheimer's disease (AD) and Type-2 Diabetes Mellitus (T2DM). Patients with both AD and …

Among the various mechanisms involved in aging, it was proposed long ago that a
prominent role is played by oxidative stress. A major way by which the latter can provoke …

Abstract Changes in the neuromuscular system affecting the ageing motor unit manifest
structurally as a reduction in motor unit number secondary to motor neuron loss; fibre type …

The free radical theory of aging proposes that reactive oxygen species (ROS)-induced
accumulation of damage to cellular macromolecules is a primary driving force of aging and a …

The field of free radicals and antioxidants, or 'redox biology', is fundamental to aerobic life.
Aerobes constantly make reactive species, but modulate their actions by synthesizing …