Chemokine receptor CCR6 is expressed on various cells such as B cells, immature dendritic
cells, innate lymphoid cells (ILCs), regulatory CD4 T cells, and Th17 cells. CCL20 is the only …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

B and T lymphocytes are the mediators of immunity, but their function is under the control of
dendritic cells. Dendritic cells in the periphery capture and process antigens, express …

Dendritic cells (DCs) are antigen-presenting cells with a unique ability to induce primary
immune responses. DCs capture and transfer information from the outside world to the cells …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Interleukin 17–producing T helper cells (T H-17 cells) are important in experimental
autoimmune encephalomyelitis, but their route of entry into the central nervous system …

During the last five years, the development of bioinformatics and EST databases has been
primarily responsible for the identification of many new chemokines and chemokine …

Defensins contribute to host defense by disrupting the cytoplasmic membrane of
microorganisms. This report shows that human β-defensins are also chemotactic for …

Chemokine receptors comprise a large family of seven transmembrane domain G protein-
coupled receptors differentially expressed in diverse cell types. Biological activities have …

The IL-1 family members IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9) and the
receptor antagonist IL-36Ra (IL-1F5) constitute a novel signaling system that is poorly …