Mitochondria are cellular organelles responsible for generation of chemical energy in the
process called oxidative phosphorylation. They originate from a bacterial ancestor and …

Perturbation of mitochondrial DNA (mtDNA) gene expression can lead to human
pathologies. Therefore, a greater appreciation of the basic mechanisms of mitochondrial …

Expanding the repertoire of electrophiles with unique reactivity features would facilitate the
development of covalent inhibitors with desirable reactivity profiles. We herein introduce …

The ribosome is a structurally and functionally conserved macromolecular machine
universally responsible for catalyzing protein synthesis. Within eukaryotic cells, mitochondria …

Mitochondria play fundamental roles in the regulation of life and death of eukaryotic cells.
They mediate aerobic energy conversion through the oxidative phosphorylation (OXPHOS) …

Although mitochondrial disorders are clinically heterogeneous, they frequently involve the
central nervous system and are among the most common neurogenetic disorders …

Oxidative phosphorylation (OXPHOS) is the mechanism whereby ATP, the major energy
source for the cell, is produced by harnessing cellular respiration in the mitochondrion. This …

Mitochondria control life and death in eukaryotic cells. Harboring a unique circular genome,
a by‐product of an ancient endosymbiotic event, mitochondria maintains a specialized and …

Human mitochondrial ribosomes are specialized in the synthesis of 13 proteins, which are
fundamental components of the oxidative phosphorylation system. The pathway of …

Mitochondrial diseases are severe and largely untreatable. Owing to the many essential
processes carried out by mitochondria and the complex cellular systems that support these …