Targeting the RdRp of emerging RNA viruses: the structure-based drug design challenge
The RNA-dependent RNA polymerase (RdRp) is an essential enzyme for the viral
replication process, catalyzing the viral RNA synthesis using a metal ion-dependent …
replication process, catalyzing the viral RNA synthesis using a metal ion-dependent …
Repurposing drugs for the management of COVID-19
J Cusinato, Y Cau, AM Calvani… - Expert opinion on …, 2021 - Taylor & Francis
Introduction: The coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 represents
a serious health issue worldwide, with more than 61 million cases and more than 1.4 million …
a serious health issue worldwide, with more than 61 million cases and more than 1.4 million …
Identification of sulphonamide-tethered N-((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main protease
SARS-CoV-2 pandemic in the end of 2019 led to profound consequences on global health
and economy. Till producing successful vaccination strategies, the healthcare sectors …
and economy. Till producing successful vaccination strategies, the healthcare sectors …
Coumarin carbonic anhydrase inhibitors from natural sources
CT Supuran - Journal of Enzyme Inhibition and Medicinal …, 2020 - Taylor & Francis
Coumarins constitute a relatively new class of inhibitors of the zinc enzyme carbonic
anhydrase (CA, EC 4.2. 1.1), possessing a unique inhibition mechanism, acting as “prodrug …
anhydrase (CA, EC 4.2. 1.1), possessing a unique inhibition mechanism, acting as “prodrug …
[PDF][PDF] COVID-19 y el trabajo decente: Cobertura de los medios de comunicación en línea sobre las trabajadoras domésticas migrantes Indonesias en Malasia y …
Entre todas las demás industrias, la propagación de COVID-19 también afectó el trabajo
formal de diferentes industrias, incluidos los trabajadores domésticos en las casas de los …
formal de diferentes industrias, incluidos los trabajadores domésticos en las casas de los …
Molecular docking and simulation studies of natural compounds of Vitex negundo L. against papain-like protease (PLpro) of SARS CoV-2 (coronavirus) to conquer …
The severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) is β-coronavirus that is
responsible for the pandemic coronavirus disease 2019 (COVID-19) all over the world. The …
responsible for the pandemic coronavirus disease 2019 (COVID-19) all over the world. The …
Zoonotic potential of Newcastle disease virus: Old and novel perspectives related to public health
Newcastle disease virus (NDV) has a worldwide distribution, causing lethal infection in a
wide range of avian species. Affected birds develop respiratory, digestive and neurologic …
wide range of avian species. Affected birds develop respiratory, digestive and neurologic …
[HTML][HTML] Invasive alien species as reservoirs for pathogens
Alien plant and animal hosts play an important role as vectors of dangerous pathogens.
However, the knowledge on pathogens of many host species is still limited. To bridge this …
However, the knowledge on pathogens of many host species is still limited. To bridge this …
Protease inhibitors targeting the main protease and papain-like protease of coronaviruses
Introduction The two cysteine proteases from the coronaviruses, which produced deadly
outbreaks in the last two decades, SARS CoV-1/2, and MERS, the main protease (Mpro) and …
outbreaks in the last two decades, SARS CoV-1/2, and MERS, the main protease (Mpro) and …
Interactions between SARS coronavirus 2 papain‐like protease and immune system: a potential drug target for the treatment of COVID‐19
S Mahmoudvand, S Shokri - Scandinavian journal of …, 2021 - Wiley Online Library
Coronaviruses (CoVs) are a large family of respiratory viruses which can cause mild to
moderate upper respiratory tract infections. Recently, new coronavirus named as Severe …
moderate upper respiratory tract infections. Recently, new coronavirus named as Severe …